Maternal smoking during pregnancy negatively affects brain volumes proportional to intracranial volume in adolescents born very preterm
Introduction Maternal smoking during pregnancy has been shown to associate with smaller frontal lobe and cerebellar volumes in brain magnetic resonance imaging (MRI) at term age in very preterm infants. The aim of this study was to examine the effect of maternal smoking during pregnancy on volumetri...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2023-04-01
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| Series: | Tobacco Prevention and Cessation |
| Subjects: | |
| Online Access: | https://www.tobaccopreventioncessation.com/Maternal-smoking-during-pregnancy-negatively-affects-brain-volumes-nproportional,162817,0,2.html |
| Summary: | Introduction
Maternal smoking during pregnancy has been shown to associate with smaller frontal
lobe and cerebellar volumes in brain magnetic resonance imaging (MRI) at term age in very
preterm infants. The aim of this study was to examine the effect of maternal smoking during
pregnancy on volumetric brain MRI findings at 13 years.
Material and Methods
Included adolescents were born very preterm (gestational age 0.05). Regarding volumes proportional to intracranial volume, the adolescents in the exposed group exhibited smaller gray matter volumes in the inferotemporal (FDR corrected p= 0.022) and parahippocampal (p=0.018) regions compared to the unexposed group. The surface area in the exposed group was also smaller in the parahippocampal (p=0.046) and postcentral (p=0.046) regions compared to the unexposed group. No significant differences were found for either curvature or cortical thickness between the groups.
Conclusions
Maternal smoking exposure during pregnancy may have long-term effects on brain
volumes up to 13 years in adolescents born very preterm. Our findings emphasize the importance of smoking-free pregnancy.
On behalf of the PIPARI Study Group. |
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| ISSN: | 2459-3087 |