Maternal smoking during pregnancy negatively affects brain volumes proportional to intracranial volume in adolescents born very preterm
Introduction Maternal smoking during pregnancy has been shown to associate with smaller frontal lobe and cerebellar volumes in brain magnetic resonance imaging (MRI) at term age in very preterm infants. The aim of this study was to examine the effect of maternal smoking during pregnancy on volumetri...
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| Format: | Article |
| Language: | English |
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European Publishing
2023-04-01
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| Series: | Tobacco Prevention and Cessation |
| Subjects: | |
| Online Access: | https://www.tobaccopreventioncessation.com/Maternal-smoking-during-pregnancy-negatively-affects-brain-volumes-nproportional,162817,0,2.html |
| _version_ | 1797338004412432384 |
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| author | Mikael O. Ekblad Peter Ngum Harri Merisaari Virva Saunavaara Riitta Parkkola Sirkku Setänen |
| author_facet | Mikael O. Ekblad Peter Ngum Harri Merisaari Virva Saunavaara Riitta Parkkola Sirkku Setänen |
| author_sort | Mikael O. Ekblad |
| collection | DOAJ |
| description | Introduction
Maternal smoking during pregnancy has been shown to associate with smaller frontal
lobe and cerebellar volumes in brain magnetic resonance imaging (MRI) at term age in very
preterm infants. The aim of this study was to examine the effect of maternal smoking during
pregnancy on volumetric brain MRI findings at 13 years.
Material and Methods
Included adolescents were born very preterm (gestational age 0.05). Regarding volumes proportional to intracranial volume, the adolescents in the exposed group exhibited smaller gray matter volumes in the inferotemporal (FDR corrected p= 0.022) and parahippocampal (p=0.018) regions compared to the unexposed group. The surface area in the exposed group was also smaller in the parahippocampal (p=0.046) and postcentral (p=0.046) regions compared to the unexposed group. No significant differences were found for either curvature or cortical thickness between the groups.
Conclusions
Maternal smoking exposure during pregnancy may have long-term effects on brain
volumes up to 13 years in adolescents born very preterm. Our findings emphasize the importance of smoking-free pregnancy.
On behalf of the PIPARI Study Group. |
| first_indexed | 2024-03-08T09:24:49Z |
| format | Article |
| id | doaj.art-3d0b4e5e05894aae9d4e2c449ac91cd6 |
| institution | Directory Open Access Journal |
| issn | 2459-3087 |
| language | English |
| last_indexed | 2024-03-08T09:24:49Z |
| publishDate | 2023-04-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Prevention and Cessation |
| spelling | doaj.art-3d0b4e5e05894aae9d4e2c449ac91cd62024-01-31T10:28:10ZengEuropean PublishingTobacco Prevention and Cessation2459-30872023-04-019Supplement10.18332/tpc/162817162817Maternal smoking during pregnancy negatively affects brain volumes proportional to intracranial volume in adolescents born very pretermMikael O. Ekblad0Peter Ngum1Harri Merisaari2Virva Saunavaara3Riitta Parkkola4Sirkku Setänen5Department of General Practice, Institute of Clinical Medicine, University of Turku and Turku University Hospital, Turku, FinlandTurku Brain Injury Center, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Radiology, University of Turku, Turku, FinlandDepartment of Medical Physics, Division of Medical Imaging, Turku University Hospital, FinlandDepartment of Radiology, University of Turku, Turku, FinlandDepartment of Pediatric Neurology, University of Turku and Turku University Hospital, Turku, FinlandIntroduction Maternal smoking during pregnancy has been shown to associate with smaller frontal lobe and cerebellar volumes in brain magnetic resonance imaging (MRI) at term age in very preterm infants. The aim of this study was to examine the effect of maternal smoking during pregnancy on volumetric brain MRI findings at 13 years. Material and Methods Included adolescents were born very preterm (gestational age 0.05). Regarding volumes proportional to intracranial volume, the adolescents in the exposed group exhibited smaller gray matter volumes in the inferotemporal (FDR corrected p= 0.022) and parahippocampal (p=0.018) regions compared to the unexposed group. The surface area in the exposed group was also smaller in the parahippocampal (p=0.046) and postcentral (p=0.046) regions compared to the unexposed group. No significant differences were found for either curvature or cortical thickness between the groups. Conclusions Maternal smoking exposure during pregnancy may have long-term effects on brain volumes up to 13 years in adolescents born very preterm. Our findings emphasize the importance of smoking-free pregnancy. On behalf of the PIPARI Study Group.https://www.tobaccopreventioncessation.com/Maternal-smoking-during-pregnancy-negatively-affects-brain-volumes-nproportional,162817,0,2.htmlcigarettefreesurferexposurelong-termmrinicotineprenatalroi |
| spellingShingle | Mikael O. Ekblad Peter Ngum Harri Merisaari Virva Saunavaara Riitta Parkkola Sirkku Setänen Maternal smoking during pregnancy negatively affects brain volumes proportional to intracranial volume in adolescents born very preterm Tobacco Prevention and Cessation cigarette freesurfer exposure long-term mri nicotine prenatal roi |
| title | Maternal smoking during pregnancy negatively affects brain volumes
proportional to intracranial volume in adolescents born very preterm |
| title_full | Maternal smoking during pregnancy negatively affects brain volumes
proportional to intracranial volume in adolescents born very preterm |
| title_fullStr | Maternal smoking during pregnancy negatively affects brain volumes
proportional to intracranial volume in adolescents born very preterm |
| title_full_unstemmed | Maternal smoking during pregnancy negatively affects brain volumes
proportional to intracranial volume in adolescents born very preterm |
| title_short | Maternal smoking during pregnancy negatively affects brain volumes
proportional to intracranial volume in adolescents born very preterm |
| title_sort | maternal smoking during pregnancy negatively affects brain volumes proportional to intracranial volume in adolescents born very preterm |
| topic | cigarette freesurfer exposure long-term mri nicotine prenatal roi |
| url | https://www.tobaccopreventioncessation.com/Maternal-smoking-during-pregnancy-negatively-affects-brain-volumes-nproportional,162817,0,2.html |
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