Clinical Significance of Elevated S100A8 Expression in Breast Cancer Patients
Breast cancer is the leading cause of female cancer-related death; however, novel biomarkers for predicting cancer recurrence still need to be explored. Aberrant expression of S100A8 has been reported to be related to tumor progression in various cancer types. This study aims to evaluate the clinica...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2018.00496/full |
| _version_ | 1818232964240113664 |
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| author | Dujuan Wang Guohong Liu Balu Wu Li Chen Lihua Zeng Yunbao Pan |
| author_facet | Dujuan Wang Guohong Liu Balu Wu Li Chen Lihua Zeng Yunbao Pan |
| author_sort | Dujuan Wang |
| collection | DOAJ |
| description | Breast cancer is the leading cause of female cancer-related death; however, novel biomarkers for predicting cancer recurrence still need to be explored. Aberrant expression of S100A8 has been reported to be related to tumor progression in various cancer types. This study aims to evaluate the clinical significance of S100A8 expression in breast cancer patients. In this study, data from 140 breast cancer patients were retrospectively collected to examine the association between S100A8 expression and clinical prognosis. Increased S100A8 expression was detected in breast cancer patients with relapse. The patients with increased S100A8 levels had significantly shorter disease-free survival (DFS) and overall survival (OS). In a multivariate survival analysis, a high histological grade and an elevated S100A8 level were independent factors associated with poor DFS and OS. Moreover, S100A8 expression was correlated with clinical subtype in breast cancer patients. The results showed that ER-negative and triple-negative breast cancer (TNBC) patients had significantly higher expression of S100A8 than patients with other subtypes. In conclusion, this study identified S100A8 as a potential biomarker for relapse in breast cancer patients. |
| first_indexed | 2024-12-12T11:14:39Z |
| format | Article |
| id | doaj.art-3d0f047a3252490a9bc479a89072b2f4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T11:14:39Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3d0f047a3252490a9bc479a89072b2f42022-12-22T00:26:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-11-01810.3389/fonc.2018.00496411732Clinical Significance of Elevated S100A8 Expression in Breast Cancer PatientsDujuan Wang0Guohong Liu1Balu Wu2Li Chen3Lihua Zeng4Yunbao Pan5Department of Clinical Pathology, Houjie Hospital of Dongguan, The Affiliated Houjie Hospital of Guangdong Medical University, Dongguan, ChinaDepartment of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, ChinaDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, ChinaDepartment of Clinical Pathology, Houjie Hospital of Dongguan, The Affiliated Houjie Hospital of Guangdong Medical University, Dongguan, ChinaDepartment of Clinical Pathology, Houjie Hospital of Dongguan, The Affiliated Houjie Hospital of Guangdong Medical University, Dongguan, ChinaDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, ChinaBreast cancer is the leading cause of female cancer-related death; however, novel biomarkers for predicting cancer recurrence still need to be explored. Aberrant expression of S100A8 has been reported to be related to tumor progression in various cancer types. This study aims to evaluate the clinical significance of S100A8 expression in breast cancer patients. In this study, data from 140 breast cancer patients were retrospectively collected to examine the association between S100A8 expression and clinical prognosis. Increased S100A8 expression was detected in breast cancer patients with relapse. The patients with increased S100A8 levels had significantly shorter disease-free survival (DFS) and overall survival (OS). In a multivariate survival analysis, a high histological grade and an elevated S100A8 level were independent factors associated with poor DFS and OS. Moreover, S100A8 expression was correlated with clinical subtype in breast cancer patients. The results showed that ER-negative and triple-negative breast cancer (TNBC) patients had significantly higher expression of S100A8 than patients with other subtypes. In conclusion, this study identified S100A8 as a potential biomarker for relapse in breast cancer patients.https://www.frontiersin.org/article/10.3389/fonc.2018.00496/fullbreast cancerS100A8relapseestrogen receptorimmunohistochemistry |
| spellingShingle | Dujuan Wang Guohong Liu Balu Wu Li Chen Lihua Zeng Yunbao Pan Clinical Significance of Elevated S100A8 Expression in Breast Cancer Patients Frontiers in Oncology breast cancer S100A8 relapse estrogen receptor immunohistochemistry |
| title | Clinical Significance of Elevated S100A8 Expression in Breast Cancer Patients |
| title_full | Clinical Significance of Elevated S100A8 Expression in Breast Cancer Patients |
| title_fullStr | Clinical Significance of Elevated S100A8 Expression in Breast Cancer Patients |
| title_full_unstemmed | Clinical Significance of Elevated S100A8 Expression in Breast Cancer Patients |
| title_short | Clinical Significance of Elevated S100A8 Expression in Breast Cancer Patients |
| title_sort | clinical significance of elevated s100a8 expression in breast cancer patients |
| topic | breast cancer S100A8 relapse estrogen receptor immunohistochemistry |
| url | https://www.frontiersin.org/article/10.3389/fonc.2018.00496/full |
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