Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes
AimsTo explore the relationship between plasma leucine-rich α-2-glycoprotein 1 (LRG1) level and the degree of urinary albumin excretion in patients with type 2 diabetes.MethodsWe evaluated 332 patients with type 2 diabetes in a cross-sectional study.ResultThe plasma LRG1 level differed significantly...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1232021/full |
| _version_ | 1797658211076014080 |
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| author | Jin Ook Chung Seon-Young Park Dong Hyeok Cho Dong Jin Chung Min Young Chung |
| author_facet | Jin Ook Chung Seon-Young Park Dong Hyeok Cho Dong Jin Chung Min Young Chung |
| author_sort | Jin Ook Chung |
| collection | DOAJ |
| description | AimsTo explore the relationship between plasma leucine-rich α-2-glycoprotein 1 (LRG1) level and the degree of urinary albumin excretion in patients with type 2 diabetes.MethodsWe evaluated 332 patients with type 2 diabetes in a cross-sectional study.ResultThe plasma LRG1 level differed significantly according to the quartiles of urinary albumin excretion (Q1 [<7.7 mg/g], 17.1 μg/mL; Q2 [7.7–15.0 mg/g], 17.5 μg/mL; Q3 [15.1–61.4 mg/g], 18.6 μg/mL; Q4 [≥61.5 mg/g], 22.3 μg/mL; p for trend = 0.003) under adjustment with other covariates. A positive correlation was found between plasma LRG1 level and urinary albumin excretion (ρ = 0.256, p <0.001). According to a multivariate model, the association between LRG1 and urinary albumin excretion remained significant, under adjustment for confounding factors (β = 0.285, p <0.001).ConclusionPlasma LRG1 level was independently associated with urinary albumin excretion in patients with type 2 diabetes. This study suggests that LRG1 may be associated with increased excretion of urinary albumin in the early stages of diabetic nephropathy. |
| first_indexed | 2024-03-11T17:55:56Z |
| format | Article |
| id | doaj.art-3d0f0c719e58495b83aa6aeeb9d194fd |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T17:55:56Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3d0f0c719e58495b83aa6aeeb9d194fd2023-10-17T12:55:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12320211232021Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetesJin Ook Chung0Seon-Young Park1Dong Hyeok Cho2Dong Jin Chung3Min Young Chung4Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaAimsTo explore the relationship between plasma leucine-rich α-2-glycoprotein 1 (LRG1) level and the degree of urinary albumin excretion in patients with type 2 diabetes.MethodsWe evaluated 332 patients with type 2 diabetes in a cross-sectional study.ResultThe plasma LRG1 level differed significantly according to the quartiles of urinary albumin excretion (Q1 [<7.7 mg/g], 17.1 μg/mL; Q2 [7.7–15.0 mg/g], 17.5 μg/mL; Q3 [15.1–61.4 mg/g], 18.6 μg/mL; Q4 [≥61.5 mg/g], 22.3 μg/mL; p for trend = 0.003) under adjustment with other covariates. A positive correlation was found between plasma LRG1 level and urinary albumin excretion (ρ = 0.256, p <0.001). According to a multivariate model, the association between LRG1 and urinary albumin excretion remained significant, under adjustment for confounding factors (β = 0.285, p <0.001).ConclusionPlasma LRG1 level was independently associated with urinary albumin excretion in patients with type 2 diabetes. This study suggests that LRG1 may be associated with increased excretion of urinary albumin in the early stages of diabetic nephropathy.https://www.frontiersin.org/articles/10.3389/fendo.2023.1232021/fullalbuminuriabiomarkersdiabetes mellitustype 2diabetic nephropathiesLRG1 protein |
| spellingShingle | Jin Ook Chung Seon-Young Park Dong Hyeok Cho Dong Jin Chung Min Young Chung Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes Frontiers in Endocrinology albuminuria biomarkers diabetes mellitus type 2 diabetic nephropathies LRG1 protein |
| title | Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes |
| title_full | Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes |
| title_fullStr | Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes |
| title_full_unstemmed | Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes |
| title_short | Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes |
| title_sort | relationship between plasma leucine rich α 2 glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes |
| topic | albuminuria biomarkers diabetes mellitus type 2 diabetic nephropathies LRG1 protein |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1232021/full |
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