The Role of Wnt Signaling in Postnatal Tooth Root Development
Appropriate tooth root formation and tooth eruption are critical for achieving and maintaining good oral health and quality of life. Tooth eruption is the process through which teeth emerge from their intraosseous position to their functional position in the oral cavity. This temporospatial process...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Dental Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2021.769134/full |
| _version_ | 1819290062074937344 |
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| author | Nicha Tokavanich Nicha Tokavanich Marc N. Wein Jeryl D. English Noriaki Ono Wanida Ono |
| author_facet | Nicha Tokavanich Nicha Tokavanich Marc N. Wein Jeryl D. English Noriaki Ono Wanida Ono |
| author_sort | Nicha Tokavanich |
| collection | DOAJ |
| description | Appropriate tooth root formation and tooth eruption are critical for achieving and maintaining good oral health and quality of life. Tooth eruption is the process through which teeth emerge from their intraosseous position to their functional position in the oral cavity. This temporospatial process occurs simultaneously with tooth root formation through a cascade of interactions between the epithelial and adjoining mesenchymal cells. Here, we will review the role of the Wnt system in postnatal tooth root development. This signaling pathway orchestrates the process of tooth root formation and tooth eruption in conjunction with several other major signaling pathways. The Wnt signaling pathway is comprised of the canonical, or Wnt/β-catenin, and the non-Canonical signaling pathway. The expression of multiple Wnt ligands and their downstream transcription factors including β-catenin is found in the cells in the epithelia and mesenchyme starting from the initiation stage of tooth development. The inhibition of canonical Wnt signaling in an early stage arrests odontogenesis. Wnt transcription factors continue to be present in dental follicle cells, the progenitor cells responsible for differentiation into cells constituting the tooth root and the periodontal tissue apparatus. This expression occurs concurrently with osteogenesis and cementogenesis. The conditional ablation of β-catenin in osteoblast and odontoblast causes the malformation of the root dentin and cementum. On the contrary, the overexpression of β-catenin led to shorter molar roots with thin and hypo-mineralized dentin, along with the failure of tooth eruption. Therefore, the proper expression of Wnt signaling during dental development is crucial for regulating the proliferation, differentiation, as well as epithelial-mesenchymal interaction essential for tooth root formation and tooth eruption. |
| first_indexed | 2024-12-24T03:16:46Z |
| format | Article |
| id | doaj.art-3d0f434ae7b144ebb2bf19161a618499 |
| institution | Directory Open Access Journal |
| issn | 2673-4915 |
| language | English |
| last_indexed | 2024-12-24T03:16:46Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj.art-3d0f434ae7b144ebb2bf19161a6184992022-12-21T17:17:36ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152021-11-01210.3389/fdmed.2021.769134769134The Role of Wnt Signaling in Postnatal Tooth Root DevelopmentNicha Tokavanich0Nicha Tokavanich1Marc N. Wein2Jeryl D. English3Noriaki Ono4Wanida Ono5Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, United StatesEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesDepartment of Orthodontics, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, United StatesDepartment of Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, United StatesDepartment of Orthodontics, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, United StatesAppropriate tooth root formation and tooth eruption are critical for achieving and maintaining good oral health and quality of life. Tooth eruption is the process through which teeth emerge from their intraosseous position to their functional position in the oral cavity. This temporospatial process occurs simultaneously with tooth root formation through a cascade of interactions between the epithelial and adjoining mesenchymal cells. Here, we will review the role of the Wnt system in postnatal tooth root development. This signaling pathway orchestrates the process of tooth root formation and tooth eruption in conjunction with several other major signaling pathways. The Wnt signaling pathway is comprised of the canonical, or Wnt/β-catenin, and the non-Canonical signaling pathway. The expression of multiple Wnt ligands and their downstream transcription factors including β-catenin is found in the cells in the epithelia and mesenchyme starting from the initiation stage of tooth development. The inhibition of canonical Wnt signaling in an early stage arrests odontogenesis. Wnt transcription factors continue to be present in dental follicle cells, the progenitor cells responsible for differentiation into cells constituting the tooth root and the periodontal tissue apparatus. This expression occurs concurrently with osteogenesis and cementogenesis. The conditional ablation of β-catenin in osteoblast and odontoblast causes the malformation of the root dentin and cementum. On the contrary, the overexpression of β-catenin led to shorter molar roots with thin and hypo-mineralized dentin, along with the failure of tooth eruption. Therefore, the proper expression of Wnt signaling during dental development is crucial for regulating the proliferation, differentiation, as well as epithelial-mesenchymal interaction essential for tooth root formation and tooth eruption.https://www.frontiersin.org/articles/10.3389/fdmed.2021.769134/fullWntsignaling pathwaytooth eruptiontooth root formationtooth development |
| spellingShingle | Nicha Tokavanich Nicha Tokavanich Marc N. Wein Jeryl D. English Noriaki Ono Wanida Ono The Role of Wnt Signaling in Postnatal Tooth Root Development Frontiers in Dental Medicine Wnt signaling pathway tooth eruption tooth root formation tooth development |
| title | The Role of Wnt Signaling in Postnatal Tooth Root Development |
| title_full | The Role of Wnt Signaling in Postnatal Tooth Root Development |
| title_fullStr | The Role of Wnt Signaling in Postnatal Tooth Root Development |
| title_full_unstemmed | The Role of Wnt Signaling in Postnatal Tooth Root Development |
| title_short | The Role of Wnt Signaling in Postnatal Tooth Root Development |
| title_sort | role of wnt signaling in postnatal tooth root development |
| topic | Wnt signaling pathway tooth eruption tooth root formation tooth development |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2021.769134/full |
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