High-dose polychemotherapy of patients with poor-prognosis anaplastic T.0-large cell ALK+ lymphosarcoma
Aim. To evaluate efficacy of the protocol NHL BFM-90 in the treatment of adult anaplastic large cell lymphosarcoma (ALCL) ALK+ and validity of addition of transplantation of autologous stem hemopoietic cells (ASHC) into first line treatment. Material and methods. We treated 13 patients with stage II...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2009-07-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30393 |
| _version_ | 1819093431191863296 |
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| author | Lidiya Gamilevna Aitova Yuliya Eykhenovna Vinogradova Irina Borisovna Kaplanskaya Irina Nikolaevna Lutsenko Evgeniy Evgen'evich Zvonkov Kira Sergeevna Momotyuk Sergey Kirillovich Kravchenko Aleksandra Mikhaylovna Kremenetskaya Andrey Ivanovich Vorob'ev L G Aitova Yu E Vinogradova I B Kaplanskaya I N Lutsenko E E Zvonkov K S Momotyuk S K Kravchenko A M Kremenetskaya A I Vorobyev |
| author_facet | Lidiya Gamilevna Aitova Yuliya Eykhenovna Vinogradova Irina Borisovna Kaplanskaya Irina Nikolaevna Lutsenko Evgeniy Evgen'evich Zvonkov Kira Sergeevna Momotyuk Sergey Kirillovich Kravchenko Aleksandra Mikhaylovna Kremenetskaya Andrey Ivanovich Vorob'ev L G Aitova Yu E Vinogradova I B Kaplanskaya I N Lutsenko E E Zvonkov K S Momotyuk S K Kravchenko A M Kremenetskaya A I Vorobyev |
| author_sort | Lidiya Gamilevna Aitova |
| collection | DOAJ |
| description | Aim. To evaluate efficacy of the protocol NHL BFM-90 in the treatment of adult anaplastic large cell lymphosarcoma (ALCL) ALK+ and validity of addition of transplantation of autologous stem hemopoietic cells (ASHC) into first line treatment.
Material and methods. We treated 13 patients with stage III-IV ALCL ALK+. The age of the patients ranged from 17 to 44 years (median 26 years). The diagnosis was made using morphological, histological, immunohistochemical methods with application of monoclonal antibodies to CD30, ALK, CD3, CD4, CD8, CD7, CD34, CD15, CD68, CD20, CD45RO, CD45RA. The patients were treated according to the protocol NHL BFM-90. ASHC was made in two patients with the disease stage IV.
Results. We obtained a complete remission in 12 of 13 patients, one woman died of infectious complications in the beginning of the treatment, one man had early recurrence 45 days after the end of the treatment with lethal outcome and disease progression. Two patients at stage IV and poor prognosis had undergone ASHC transplantation. They are now in remission for 5 and 12 months.
Conclusion. ALCL ALK+ is characterized by an aggressive clinical course (11 of 13 patients had stage III-IV), high rate of extranodal lesions. Twelve patients achieved a complete remission, 11 (91.6%) of 12 patients are alive in observation median 27 months. We effectively used ASHC transplantation in the first-line treatment of 2 patients with stage IV of the disease and poor prognosis. |
| first_indexed | 2024-12-21T23:11:24Z |
| format | Article |
| id | doaj.art-3d114f5d5e4542fa977d3b16e6e2c39e |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-21T23:11:24Z |
| publishDate | 2009-07-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-3d114f5d5e4542fa977d3b16e6e2c39e2022-12-21T18:47:01Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422009-07-01817535727420High-dose polychemotherapy of patients with poor-prognosis anaplastic T.0-large cell ALK+ lymphosarcomaLidiya Gamilevna AitovaYuliya Eykhenovna VinogradovaIrina Borisovna KaplanskayaIrina Nikolaevna LutsenkoEvgeniy Evgen'evich ZvonkovKira Sergeevna MomotyukSergey Kirillovich KravchenkoAleksandra Mikhaylovna KremenetskayaAndrey Ivanovich Vorob'evL G AitovaYu E VinogradovaI B KaplanskayaI N LutsenkoE E ZvonkovK S MomotyukS K KravchenkoA M KremenetskayaA I VorobyevAim. To evaluate efficacy of the protocol NHL BFM-90 in the treatment of adult anaplastic large cell lymphosarcoma (ALCL) ALK+ and validity of addition of transplantation of autologous stem hemopoietic cells (ASHC) into first line treatment. Material and methods. We treated 13 patients with stage III-IV ALCL ALK+. The age of the patients ranged from 17 to 44 years (median 26 years). The diagnosis was made using morphological, histological, immunohistochemical methods with application of monoclonal antibodies to CD30, ALK, CD3, CD4, CD8, CD7, CD34, CD15, CD68, CD20, CD45RO, CD45RA. The patients were treated according to the protocol NHL BFM-90. ASHC was made in two patients with the disease stage IV. Results. We obtained a complete remission in 12 of 13 patients, one woman died of infectious complications in the beginning of the treatment, one man had early recurrence 45 days after the end of the treatment with lethal outcome and disease progression. Two patients at stage IV and poor prognosis had undergone ASHC transplantation. They are now in remission for 5 and 12 months. Conclusion. ALCL ALK+ is characterized by an aggressive clinical course (11 of 13 patients had stage III-IV), high rate of extranodal lesions. Twelve patients achieved a complete remission, 11 (91.6%) of 12 patients are alive in observation median 27 months. We effectively used ASHC transplantation in the first-line treatment of 2 patients with stage IV of the disease and poor prognosis.https://ter-arkhiv.ru/0040-3660/article/view/30393nhl-bfm-90anaplastic alk+ lymphosarcomanhl bfm-90transplantation of autologous stem cells of bloodfactors of poor prognosis |
| spellingShingle | Lidiya Gamilevna Aitova Yuliya Eykhenovna Vinogradova Irina Borisovna Kaplanskaya Irina Nikolaevna Lutsenko Evgeniy Evgen'evich Zvonkov Kira Sergeevna Momotyuk Sergey Kirillovich Kravchenko Aleksandra Mikhaylovna Kremenetskaya Andrey Ivanovich Vorob'ev L G Aitova Yu E Vinogradova I B Kaplanskaya I N Lutsenko E E Zvonkov K S Momotyuk S K Kravchenko A M Kremenetskaya A I Vorobyev High-dose polychemotherapy of patients with poor-prognosis anaplastic T.0-large cell ALK+ lymphosarcoma Терапевтический архив nhl-bfm-90 anaplastic alk+ lymphosarcoma nhl bfm-90 transplantation of autologous stem cells of blood factors of poor prognosis |
| title | High-dose polychemotherapy of patients with poor-prognosis anaplastic T.0-large cell ALK+ lymphosarcoma |
| title_full | High-dose polychemotherapy of patients with poor-prognosis anaplastic T.0-large cell ALK+ lymphosarcoma |
| title_fullStr | High-dose polychemotherapy of patients with poor-prognosis anaplastic T.0-large cell ALK+ lymphosarcoma |
| title_full_unstemmed | High-dose polychemotherapy of patients with poor-prognosis anaplastic T.0-large cell ALK+ lymphosarcoma |
| title_short | High-dose polychemotherapy of patients with poor-prognosis anaplastic T.0-large cell ALK+ lymphosarcoma |
| title_sort | high dose polychemotherapy of patients with poor prognosis anaplastic t 0 large cell alk lymphosarcoma |
| topic | nhl-bfm-90 anaplastic alk+ lymphosarcoma nhl bfm-90 transplantation of autologous stem cells of blood factors of poor prognosis |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30393 |
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