Nonalcoholic fatty liver disease: cause or consequence of insulin resistance?
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are pathological conditions that are co-occurring, and have been reaching epidemic proportions. One of the most significant risk factors for the development of both T2DM and NAFLD is obesity, which increases existing insuli...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2017-12-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/9372 |
| _version_ | 1797255199116492800 |
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| author | Ekaterina E. Mishina Alexander Y. Mayorov Pavel O. Bogomolov Maria V. Matsievich Ksenia Y. Kokina Apollinariya V. Bogolyubova |
| author_facet | Ekaterina E. Mishina Alexander Y. Mayorov Pavel O. Bogomolov Maria V. Matsievich Ksenia Y. Kokina Apollinariya V. Bogolyubova |
| author_sort | Ekaterina E. Mishina |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are pathological conditions that are co-occurring, and have been reaching epidemic proportions. One of the most significant risk factors for the development of both T2DM and NAFLD is obesity, which increases existing insulin resistance (IR). IR thought to be one of the main pathogenic causes linking T2DM and NAFLD. In recent years, there has been increased interest in obtaining non-invasive methods for assessing fibrosis and determining indications for liver biopsy, such as the NAFLD fibrosis score, extended liver fibrosis panel, and transient elastography. However, liver biopsy remains the gold standard for diagnosing NAFLD. Given that patients with T2DM are at higher risk of NAFLD than the general population, and that the presence of diabetes is a risk factor for the progression of NAFLD, patients with T2DM should be more closely monitored by clinicians. The present review paper is devoted to the search for cause–effect relationships of concurrent diseases such as NAFLD and disorders of carbohydrate metabolism, and priority areas of diagnosis of NAFLD. |
| first_indexed | 2024-03-08T15:20:00Z |
| format | Article |
| id | doaj.art-3d1191129ff645dcbb017e7f0dab037a |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:02:03Z |
| publishDate | 2017-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-3d1191129ff645dcbb017e7f0dab037a2024-03-20T11:48:01ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782017-12-0120533534310.14341/DM93728374Nonalcoholic fatty liver disease: cause or consequence of insulin resistance?Ekaterina E. Mishina0Alexander Y. Mayorov1Pavel O. Bogomolov2Maria V. Matsievich3Ksenia Y. Kokina4Apollinariya V. Bogolyubova5<p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>Moscow Area Moscows regional research clinical institute n.a. M.F. Vladimirskiy</p><p>Moscow Area Moscows regional research clinical institute n.a. M.F. Vladimirskiy</p><p>Moscow Area Moscows regional research clinical institute n.a. M.F. Vladimirskiy</p><p>Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences</p>Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are pathological conditions that are co-occurring, and have been reaching epidemic proportions. One of the most significant risk factors for the development of both T2DM and NAFLD is obesity, which increases existing insulin resistance (IR). IR thought to be one of the main pathogenic causes linking T2DM and NAFLD. In recent years, there has been increased interest in obtaining non-invasive methods for assessing fibrosis and determining indications for liver biopsy, such as the NAFLD fibrosis score, extended liver fibrosis panel, and transient elastography. However, liver biopsy remains the gold standard for diagnosing NAFLD. Given that patients with T2DM are at higher risk of NAFLD than the general population, and that the presence of diabetes is a risk factor for the progression of NAFLD, patients with T2DM should be more closely monitored by clinicians. The present review paper is devoted to the search for cause–effect relationships of concurrent diseases such as NAFLD and disorders of carbohydrate metabolism, and priority areas of diagnosis of NAFLD.https://www.dia-endojournals.ru/jour/article/view/9372insulin resistancediabetes mellitusnonalcoholic fatty liver diseasenonalcoholic steatohepatitisobesity |
| spellingShingle | Ekaterina E. Mishina Alexander Y. Mayorov Pavel O. Bogomolov Maria V. Matsievich Ksenia Y. Kokina Apollinariya V. Bogolyubova Nonalcoholic fatty liver disease: cause or consequence of insulin resistance? Сахарный диабет insulin resistance diabetes mellitus nonalcoholic fatty liver disease nonalcoholic steatohepatitis obesity |
| title | Nonalcoholic fatty liver disease: cause or consequence of insulin resistance? |
| title_full | Nonalcoholic fatty liver disease: cause or consequence of insulin resistance? |
| title_fullStr | Nonalcoholic fatty liver disease: cause or consequence of insulin resistance? |
| title_full_unstemmed | Nonalcoholic fatty liver disease: cause or consequence of insulin resistance? |
| title_short | Nonalcoholic fatty liver disease: cause or consequence of insulin resistance? |
| title_sort | nonalcoholic fatty liver disease cause or consequence of insulin resistance |
| topic | insulin resistance diabetes mellitus nonalcoholic fatty liver disease nonalcoholic steatohepatitis obesity |
| url | https://www.dia-endojournals.ru/jour/article/view/9372 |
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