Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children
PurposeThe aims of this study were to compare serum procalcitonin (PCT) levels between febrile children with Kawasaki disease (KD) and those with bacterial or viral infections, and assess the clinical usefulness of PCT level in predicting KD.MethodsSerum PCT levels were examined in febrile pediatric...
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2017-04-01
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| Series: | Korean Journal of Pediatrics |
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| Online Access: | http://kjp.or.kr/upload/pdf/kjped-60-112.pdf |
| _version_ | 1811308002292006912 |
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| author | Na Hyun Lee Hee Joung Choi Yeo Hyang Kim |
| author_facet | Na Hyun Lee Hee Joung Choi Yeo Hyang Kim |
| author_sort | Na Hyun Lee |
| collection | DOAJ |
| description | PurposeThe aims of this study were to compare serum procalcitonin (PCT) levels between febrile children with Kawasaki disease (KD) and those with bacterial or viral infections, and assess the clinical usefulness of PCT level in predicting KD.MethodsSerum PCT levels were examined in febrile pediatric patients admitted between August 2013 and August 2014. The patients were divided into 3 groups as follows: 49 with KD, 111 with viral infections, and 24 with bacterial infections.ResultsThe mean PCT level in the KD group was significantly lower than that in the bacterial infection group (0.82±1.73 ng/mL vs. 3.11±6.10 ng/mL, P=0.002) and insignificantly different from that in the viral infection group (0.23±0.34 ng/mL,P=0.457). The mean erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level in the KD group were significantly higher than those in the viral and bacterial infection groups (P<0.001 and P<0.001 for ESR, P<0.001 and P=0.005 for CRP, respectively). The proportion of patients in the KD group with PCT levels of >1.0 ng/mL was significantly higher in the nonresponders to the initial intravenous immunoglobulin treatment than in the responders (36% vs. 8%, P=0.01).ConclusionPCT levels may help to differentiate KD from bacterial infections. A combination of disease markers, including ESR, CRP, and PCT, may be useful for differentiating between KD and viral/bacterial infections. |
| first_indexed | 2024-04-13T09:14:13Z |
| format | Article |
| id | doaj.art-3d132aa4c327452ab130f7d22944f361 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-04-13T09:14:13Z |
| publishDate | 2017-04-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-3d132aa4c327452ab130f7d22944f3612022-12-22T02:52:46ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582017-04-0160411211710.3345/kjp.2017.60.4.11220125550645Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile childrenNa Hyun Lee0Hee Joung Choi1Yeo Hyang Kim2Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea.Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea.Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.PurposeThe aims of this study were to compare serum procalcitonin (PCT) levels between febrile children with Kawasaki disease (KD) and those with bacterial or viral infections, and assess the clinical usefulness of PCT level in predicting KD.MethodsSerum PCT levels were examined in febrile pediatric patients admitted between August 2013 and August 2014. The patients were divided into 3 groups as follows: 49 with KD, 111 with viral infections, and 24 with bacterial infections.ResultsThe mean PCT level in the KD group was significantly lower than that in the bacterial infection group (0.82±1.73 ng/mL vs. 3.11±6.10 ng/mL, P=0.002) and insignificantly different from that in the viral infection group (0.23±0.34 ng/mL,P=0.457). The mean erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level in the KD group were significantly higher than those in the viral and bacterial infection groups (P<0.001 and P<0.001 for ESR, P<0.001 and P=0.005 for CRP, respectively). The proportion of patients in the KD group with PCT levels of >1.0 ng/mL was significantly higher in the nonresponders to the initial intravenous immunoglobulin treatment than in the responders (36% vs. 8%, P=0.01).ConclusionPCT levels may help to differentiate KD from bacterial infections. A combination of disease markers, including ESR, CRP, and PCT, may be useful for differentiating between KD and viral/bacterial infections.http://kjp.or.kr/upload/pdf/kjped-60-112.pdfBacteriaCalcitoninInfectionMucocutaneous lymph node syndromeBacterial infections |
| spellingShingle | Na Hyun Lee Hee Joung Choi Yeo Hyang Kim Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children Korean Journal of Pediatrics Bacteria Calcitonin Infection Mucocutaneous lymph node syndrome Bacterial infections |
| title | Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
| title_full | Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
| title_fullStr | Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
| title_full_unstemmed | Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
| title_short | Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
| title_sort | clinical usefulness of serum procalcitonin level in distinguishing between kawasaki disease and other infections in febrile children |
| topic | Bacteria Calcitonin Infection Mucocutaneous lymph node syndrome Bacterial infections |
| url | http://kjp.or.kr/upload/pdf/kjped-60-112.pdf |
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