YKL-40 promotes chemokine expression following drug-induced liver injury via TF-PAR1 pathway in mice

YKL-40 promotes chemokine expression following drug-induced liver injury via TF-PAR1 pathway in mice

Background: The inflammatory factor YKL-40 is associated with various inflammatory diseases and is key to remodeling inflammatory cells and tissues. YKL-40 (Chi3l1) promotes the activation of tissue factor (TF), leading to intrahepatic vascular coagulation (IAOC) and liver injury. TF is a key promot...

Full description

Bibliographic Details
Main Authors: Zhan Jing-Lun, Chai Shuang, Zhao Li-Mei, Liu Xiao-Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
YKL-40
TF-PAR1 pathway
inflammation
liver injury
CCL2
IP-10
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1205062/full

Similar Items

Similar Items