Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy

Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy

T cell dysfunction occurs early following HIV infection, impacting the emergence of non-AIDS morbidities and limiting curative efforts. ART initiated during primary HIV infection (PHI) can reverse this dysfunction, but the extent of recovery is unknown. We studied 66 HIV-infected individuals treated...

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Bibliographic Details
Main Authors: Genevieve E. Martin, Debattama R. Sen, Matthew Pace, Nicola Robinson, Jodi Meyerowitz, Emily Adland, John P. Thornhill, Mathew Jones, Ane Ogbe, Lucia Parolini, Natalia Olejniczak, Panagiota Zacharopoulou, Helen Brown, Christian B. Willberg, Nneka Nwokolo, Julie Fox, Sarah Fidler, W. Nicholas Haining, John Frater
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
HIV
T cells
Primary HIV infection (PHI)
Antiretroviral therapy (ART)
Immune exhaustion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.647688/full

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