Effects of STING stimulation on macrophages: STING agonists polarize into “classically” or “alternatively” activated macrophages?

Effects of STING stimulation on macrophages: STING agonists polarize into “classically” or “alternatively” activated macrophages?

Stimulator of interferon genes (STING) was defined as an important molecule for promoting antitumor immunity through mediating type I interferon (IFN) production by sensing its ligands such as cyclic GMP-AMP (cGAMP). Our recent study indeed demonstrated that intratumoral injection of cGAMP showed ef...

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Bibliographic Details
Main Authors: Takayuki Ohkuri, Akemi Kosaka, Toshihiro Nagato, Hiroya Kobayashi
Format: Article
Language:English
Published: Taylor & Francis Group 2018-02-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
sting
macrophage polarization
cgamp
cancer immunotherapy
tumor microenvironment
Online Access:http://dx.doi.org/10.1080/21645515.2017.1395995

Internet

http://dx.doi.org/10.1080/21645515.2017.1395995

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