Targeted cortical reorganization using optogenetics in non-human primates
Brain stimulation modulates the excitability of neural circuits and drives neuroplasticity. While the local effects of stimulation have been an active area of investigation, the effects on large-scale networks remain largely unexplored. We studied stimulation-induced changes in network dynamics in t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-05-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/31034 |
| _version_ | 1811181077658599424 |
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| author | Azadeh Yazdan-Shahmorad Daniel B Silversmith Viktor Kharazia Philip N Sabes |
| author_facet | Azadeh Yazdan-Shahmorad Daniel B Silversmith Viktor Kharazia Philip N Sabes |
| author_sort | Azadeh Yazdan-Shahmorad |
| collection | DOAJ |
| description | Brain stimulation modulates the excitability of neural circuits and drives neuroplasticity. While the local effects of stimulation have been an active area of investigation, the effects on large-scale networks remain largely unexplored. We studied stimulation-induced changes in network dynamics in two macaques. A large-scale optogenetic interface enabled simultaneous stimulation of excitatory neurons and electrocorticographic recording across primary somatosensory (S1) and motor (M1) cortex (Yazdan-Shahmorad et al., 2016). We tracked two measures of network connectivity, the network response to focal stimulation and the baseline coherence between pairs of electrodes; these were strongly correlated before stimulation. Within minutes, stimulation in S1 or M1 significantly strengthened the gross functional connectivity between these areas. At a finer scale, stimulation led to heterogeneous connectivity changes across the network. These changes reflected the correlations introduced by stimulation-evoked activity, consistent with Hebbian plasticity models. This work extends Hebbian plasticity models to large-scale circuits, with significant implications for stimulation-based neurorehabilitation. |
| first_indexed | 2024-04-11T09:13:42Z |
| format | Article |
| id | doaj.art-3d174b4951b14efba5702b3dce0bc5ce |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:13:42Z |
| publishDate | 2018-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-3d174b4951b14efba5702b3dce0bc5ce2022-12-22T04:32:26ZengeLife Sciences Publications LtdeLife2050-084X2018-05-01710.7554/eLife.31034Targeted cortical reorganization using optogenetics in non-human primatesAzadeh Yazdan-Shahmorad0https://orcid.org/0000-0001-5212-509XDaniel B Silversmith1https://orcid.org/0000-0003-1771-1856Viktor Kharazia2Philip N Sabes3https://orcid.org/0000-0001-8397-6225Department of Physiology, University of California, San Francisco, San Francisco, United States; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States; Departments of Bioengineering and Electrical Engineering, University of Washington, Seattle, United StatesCenter for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States; UC Berkeley – UCSF Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, United StatesCenter for Integrative Neuroscience, University of California, San Francisco, San Francisco, United StatesDepartment of Physiology, University of California, San Francisco, San Francisco, United States; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States; UC Berkeley – UCSF Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, United StatesBrain stimulation modulates the excitability of neural circuits and drives neuroplasticity. While the local effects of stimulation have been an active area of investigation, the effects on large-scale networks remain largely unexplored. We studied stimulation-induced changes in network dynamics in two macaques. A large-scale optogenetic interface enabled simultaneous stimulation of excitatory neurons and electrocorticographic recording across primary somatosensory (S1) and motor (M1) cortex (Yazdan-Shahmorad et al., 2016). We tracked two measures of network connectivity, the network response to focal stimulation and the baseline coherence between pairs of electrodes; these were strongly correlated before stimulation. Within minutes, stimulation in S1 or M1 significantly strengthened the gross functional connectivity between these areas. At a finer scale, stimulation led to heterogeneous connectivity changes across the network. These changes reflected the correlations introduced by stimulation-evoked activity, consistent with Hebbian plasticity models. This work extends Hebbian plasticity models to large-scale circuits, with significant implications for stimulation-based neurorehabilitation.https://elifesciences.org/articles/31034optogeneticsnon-human primatesneuromodulationplasticityneural stimulationfunctional connectivity |
| spellingShingle | Azadeh Yazdan-Shahmorad Daniel B Silversmith Viktor Kharazia Philip N Sabes Targeted cortical reorganization using optogenetics in non-human primates eLife optogenetics non-human primates neuromodulation plasticity neural stimulation functional connectivity |
| title | Targeted cortical reorganization using optogenetics in non-human primates |
| title_full | Targeted cortical reorganization using optogenetics in non-human primates |
| title_fullStr | Targeted cortical reorganization using optogenetics in non-human primates |
| title_full_unstemmed | Targeted cortical reorganization using optogenetics in non-human primates |
| title_short | Targeted cortical reorganization using optogenetics in non-human primates |
| title_sort | targeted cortical reorganization using optogenetics in non human primates |
| topic | optogenetics non-human primates neuromodulation plasticity neural stimulation functional connectivity |
| url | https://elifesciences.org/articles/31034 |
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