Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis
Hypertriglyceridemia-associated acute pancreatitis (HTGAP) is linked with increased severity and morbidity. Intestinal flora plays an important role in the progression of acute pancreatitis (AP). However, pathogenetic association between gut microbiota and HTGAP remains unknown. In this study, we en...
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MDPI AG
2021-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/5/695 |
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| author | Xiaomin Hu Liang Gong Ruilin Zhou Ziying Han Li Ji Yan Zhang Shuyang Zhang Dong Wu |
| author_facet | Xiaomin Hu Liang Gong Ruilin Zhou Ziying Han Li Ji Yan Zhang Shuyang Zhang Dong Wu |
| author_sort | Xiaomin Hu |
| collection | DOAJ |
| description | Hypertriglyceridemia-associated acute pancreatitis (HTGAP) is linked with increased severity and morbidity. Intestinal flora plays an important role in the progression of acute pancreatitis (AP). However, pathogenetic association between gut microbiota and HTGAP remains unknown. In this study, we enrolled 30 HTGAP patients and 30 patients with AP that is evoked by other causes. The V3–V4 regions of 16S rRNA sequences of the gut microbiota were analyzed. Clinical characteristics, microbial diversity, taxonomic profile, microbiome composition, microbiological phenotype, and functional pathways were compared between the two groups. Our results showed that the HTGAP group had a higher proportion of severe AP (46.7% vs. 20.0%), organ failure (56.7% vs. 30.0%), and a longer hospital stay (18.0 days vs. 6.5 days). HTGAP group also had poorer microbial diversity, higher abundances of <i>Escherichia/Shigella</i> and <i>Enterococcus</i>, but lower abundances of <i>Dorea longicatena</i>, <i>Blautia wexlerae</i>, and <i>Bacteroides ovatus</i> as compared with non-HTGAP group. Correlation analysis revealed that gut bacterial taxonomic and functional changes were linked with local and systemic complications, ICU admission, and mortality. This study revealed that alterations of gut microbiota were associated with disease severity and poor prognosis in HTGAP patients, indicating a potential pathophysiological link between gut microbiota and hypertriglyceridemia related acute pancreatitis. |
| first_indexed | 2024-03-10T11:40:17Z |
| format | Article |
| id | doaj.art-3d1821abf51e4e7e882ce997c31ec3d6 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T11:40:17Z |
| publishDate | 2021-05-01 |
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| series | Biomolecules |
| spelling | doaj.art-3d1821abf51e4e7e882ce997c31ec3d62023-11-21T18:32:28ZengMDPI AGBiomolecules2218-273X2021-05-0111569510.3390/biom11050695Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute PancreatitisXiaomin Hu0Liang Gong1Ruilin Zhou2Ziying Han3Li Ji4Yan Zhang5Shuyang Zhang6Dong Wu7Department of Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, ChinaDepartment of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaInstitute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, School of Basic Medical Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, ChinaDepartment of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaHypertriglyceridemia-associated acute pancreatitis (HTGAP) is linked with increased severity and morbidity. Intestinal flora plays an important role in the progression of acute pancreatitis (AP). However, pathogenetic association between gut microbiota and HTGAP remains unknown. In this study, we enrolled 30 HTGAP patients and 30 patients with AP that is evoked by other causes. The V3–V4 regions of 16S rRNA sequences of the gut microbiota were analyzed. Clinical characteristics, microbial diversity, taxonomic profile, microbiome composition, microbiological phenotype, and functional pathways were compared between the two groups. Our results showed that the HTGAP group had a higher proportion of severe AP (46.7% vs. 20.0%), organ failure (56.7% vs. 30.0%), and a longer hospital stay (18.0 days vs. 6.5 days). HTGAP group also had poorer microbial diversity, higher abundances of <i>Escherichia/Shigella</i> and <i>Enterococcus</i>, but lower abundances of <i>Dorea longicatena</i>, <i>Blautia wexlerae</i>, and <i>Bacteroides ovatus</i> as compared with non-HTGAP group. Correlation analysis revealed that gut bacterial taxonomic and functional changes were linked with local and systemic complications, ICU admission, and mortality. This study revealed that alterations of gut microbiota were associated with disease severity and poor prognosis in HTGAP patients, indicating a potential pathophysiological link between gut microbiota and hypertriglyceridemia related acute pancreatitis.https://www.mdpi.com/2218-273X/11/5/695acute pancreatitisgut microbiotahypertriglyceridemiaprognosis |
| spellingShingle | Xiaomin Hu Liang Gong Ruilin Zhou Ziying Han Li Ji Yan Zhang Shuyang Zhang Dong Wu Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis Biomolecules acute pancreatitis gut microbiota hypertriglyceridemia prognosis |
| title | Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis |
| title_full | Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis |
| title_fullStr | Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis |
| title_full_unstemmed | Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis |
| title_short | Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis |
| title_sort | variations in gut microbiome are associated with prognosis of hypertriglyceridemia associated acute pancreatitis |
| topic | acute pancreatitis gut microbiota hypertriglyceridemia prognosis |
| url | https://www.mdpi.com/2218-273X/11/5/695 |
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