Heat shock protein 40 of Streptococcus pneumoniae induces immune response of human dendritic cells via TLR4‐dependent p38 MAPK and JNK signaling pathways

Heat shock protein 40 of Streptococcus pneumoniae induces immune response of human dendritic cells via TLR4‐dependent p38 MAPK and JNK signaling pathways

Abstract Introduction Heat shock protein 40 (HSP40) is a vaccine adjuvant candidate for Streptococcus pneumoniae. The mechanism by which HSP40 activates the human dendritic cells (DCs) is unclear. Methods DCs were isolated from human peripheral blood and their markers (HLA‐DR, CD86, CD83, and CD80)...

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Bibliographic Details
Main Authors: Jing‐jing Liu, Jian‐cheng Lin, Li‐na Chen
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Immunity, Inflammation and Disease
Subjects:
dendritic cells
Heat shock protein 40
Jun N‐terminal kinase
p38 mitogen‐activated protein kinase
toll‐like receptor 4
Online Access:https://doi.org/10.1002/iid3.735

Internet

https://doi.org/10.1002/iid3.735

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