Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors

Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors

The immune checkpoint inhibitor (ICI) ipilimumab has revolutionized the treatment of patients with different cancer histologies, including melanoma, renal cell carcinoma, and non-small cell lung carcinoma. However, only a subset of patients shows dramatic clinical responses to treatment. Despite int...

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Bibliographic Details
Main Authors: Nicola J. Mason, Nicholas Chester, Ailian Xiong, Antonia Rotolo, Ying Wu, Sho Yoshimoto, Patrick Glassman, Gayathri Gulendran, Don L. Siegel
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:mAbs
Subjects:
Checkpoint inhibitor
canine
CTLA4
large animal model
monoclonal antibody
single chain variable fragment
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2021.2004638

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