Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample
Abstract Background Chronic kidney disease (CKD) and end stage renal disease (ESRD) are not well characterized in prostate cancer patients. This study aimed to examine the clinical characteristics and postsurgical outcomes of patients with or without CKD and ESRD undergoing radical prostatectomy for...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-019-1455-2 |
| _version_ | 1818030133917777920 |
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| author | Chen Ning Xinyi Hu Fangming Liu Jun Lin Jian Zhang Zhipeng Wang Yichen Zhu |
| author_facet | Chen Ning Xinyi Hu Fangming Liu Jun Lin Jian Zhang Zhipeng Wang Yichen Zhu |
| author_sort | Chen Ning |
| collection | DOAJ |
| description | Abstract Background Chronic kidney disease (CKD) and end stage renal disease (ESRD) are not well characterized in prostate cancer patients. This study aimed to examine the clinical characteristics and postsurgical outcomes of patients with or without CKD and ESRD undergoing radical prostatectomy for prostate cancer. Methods This population-based, retrospective study used patient data from the Nationwide Inpatient Sample, the largest all-payer US inpatient care database. From 2005 to 2014, 136,790 male patients aged > 20 years diagnosed with prostate cancer and who received radical prostatectomy were included. Postoperative complications, postoperative acute kidney injury (AKI) and urinary complications, and length of hospital stay were compared between patients with or without underlying CKD and ESRD. Results After adjusting for relevant factors, the CKD group had a significantly higher risk of postoperative complications than the non-CKD group. In addition, the CKD group had a 5-times greater risk of postoperative AKI and urinary complications than the non-CKD group. Both CKD and ESRD groups had significantly longer hospital stays than the non-CKD group. Patients receiving RARP had a lower risk of postoperative complications than those who received open radical prostatectomy, regardless of having CKD or not. Both non-CKD and CKD patients receiving RARP had shorter hospital stays than those who received open surgery. Conclusions Prostate cancer patients with underlying CKD had significantly greater risk of postoperative complications, postoperative AKI and urinary complications, and longer hospital stays than those without CKD. The use of RARP significantly shortened hospital stays and reduced complications for these patients. |
| first_indexed | 2024-12-10T05:30:45Z |
| format | Article |
| id | doaj.art-3d1cd477cf0e42abbe7206bcdbb49ed9 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-10T05:30:45Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-3d1cd477cf0e42abbe7206bcdbb49ed92022-12-22T02:00:33ZengBMCBMC Nephrology1471-23692019-07-012011910.1186/s12882-019-1455-2Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient SampleChen Ning0Xinyi Hu1Fangming Liu2Jun Lin3Jian Zhang4Zhipeng Wang5Yichen Zhu6Department of Urology, Capital Medical University Beijing Friendship HospitalDepartment of Urology, Capital Medical University Beijing Friendship HospitalDepartment of Urology, Capital Medical University Beijing Friendship HospitalDepartment of Urology, Capital Medical University Beijing Friendship HospitalDepartment of Urology, Capital Medical University Beijing Friendship HospitalDepartment of Urology, Capital Medical University Beijing Friendship HospitalDepartment of Urology, Capital Medical University Beijing Friendship HospitalAbstract Background Chronic kidney disease (CKD) and end stage renal disease (ESRD) are not well characterized in prostate cancer patients. This study aimed to examine the clinical characteristics and postsurgical outcomes of patients with or without CKD and ESRD undergoing radical prostatectomy for prostate cancer. Methods This population-based, retrospective study used patient data from the Nationwide Inpatient Sample, the largest all-payer US inpatient care database. From 2005 to 2014, 136,790 male patients aged > 20 years diagnosed with prostate cancer and who received radical prostatectomy were included. Postoperative complications, postoperative acute kidney injury (AKI) and urinary complications, and length of hospital stay were compared between patients with or without underlying CKD and ESRD. Results After adjusting for relevant factors, the CKD group had a significantly higher risk of postoperative complications than the non-CKD group. In addition, the CKD group had a 5-times greater risk of postoperative AKI and urinary complications than the non-CKD group. Both CKD and ESRD groups had significantly longer hospital stays than the non-CKD group. Patients receiving RARP had a lower risk of postoperative complications than those who received open radical prostatectomy, regardless of having CKD or not. Both non-CKD and CKD patients receiving RARP had shorter hospital stays than those who received open surgery. Conclusions Prostate cancer patients with underlying CKD had significantly greater risk of postoperative complications, postoperative AKI and urinary complications, and longer hospital stays than those without CKD. The use of RARP significantly shortened hospital stays and reduced complications for these patients.http://link.springer.com/article/10.1186/s12882-019-1455-2Chronic kidney disease (CKD)End-stage renal disease (ESRD)Prostate cancerRadical prostatectomyRobot-assistedNational Inpatient Sample (NIS) |
| spellingShingle | Chen Ning Xinyi Hu Fangming Liu Jun Lin Jian Zhang Zhipeng Wang Yichen Zhu Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample BMC Nephrology Chronic kidney disease (CKD) End-stage renal disease (ESRD) Prostate cancer Radical prostatectomy Robot-assisted National Inpatient Sample (NIS) |
| title | Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample |
| title_full | Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample |
| title_fullStr | Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample |
| title_full_unstemmed | Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample |
| title_short | Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample |
| title_sort | post surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy 10 year results from the us national inpatient sample |
| topic | Chronic kidney disease (CKD) End-stage renal disease (ESRD) Prostate cancer Radical prostatectomy Robot-assisted National Inpatient Sample (NIS) |
| url | http://link.springer.com/article/10.1186/s12882-019-1455-2 |
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