Efficacy of continuous positive airway pressure on TNF-α in obstructive sleep apnea patients: A meta-analysis
<h4>Background</h4> Tumor necrosis factor-α (TNF-α) is an important mediator of the immune response. At present, the improvement of TNF-α after continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) is still controversial. <h4>Meth...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035913/?tool=EBI |
| _version_ | 1797860144117186560 |
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| author | Yong Luo Fa-Rong Zhang Jun-Lin Wu Xi-Jiao Jiang |
| author_facet | Yong Luo Fa-Rong Zhang Jun-Lin Wu Xi-Jiao Jiang |
| author_sort | Yong Luo |
| collection | DOAJ |
| description | <h4>Background</h4> Tumor necrosis factor-α (TNF-α) is an important mediator of the immune response. At present, the improvement of TNF-α after continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) is still controversial. <h4>Methods</h4> We conducted a systematic review of the present evidence based on a meta-analysis to elucidate the effects of TNF-α on OSAHS after CPAP treatment. <h4>Results</h4> To measure TNF-α, ten studies used enzyme-linked immunosorbent assay (ELISA), and one used radioimmunoassay. The forest plot outcome indicated that CPAP therapy would lower the TNF-α levels in OSAHS patients, with a weighted mean difference (WMD) of 1.08 (95% CI: 0.62–1.55; P < 0.001) based on the REM since there is highly significant heterogeneity (I2 = 90%) among the studies. Therefore, we used the subgroup and sensitivity analyses to investigate the source of heterogeneity. The findings of the sensitivity analysis revealed that the pooled WMD ranged from 0.91 (95% CI: 0.52–1.31; P < 0.001) to 1.18 (95% CI: 0.74–1.63; P < 0.001). The findings were not influenced by any single study. Notably, there was homogeneity in the Asia subgroup and publication year: 2019, implying that these subgroups could be the source of heterogeneity. <h4>Conclusion</h4> Our meta-analysis recommends that CPAP therapy will decrease the TNF-α level in OSAHS patients, but more related research should be conducted. |
| first_indexed | 2024-04-09T21:41:02Z |
| format | Article |
| id | doaj.art-3d21c91d67f743c59a108b6512dc5dc5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T21:41:02Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3d21c91d67f743c59a108b6512dc5dc52023-03-26T05:32:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01183Efficacy of continuous positive airway pressure on TNF-α in obstructive sleep apnea patients: A meta-analysisYong LuoFa-Rong ZhangJun-Lin WuXi-Jiao Jiang<h4>Background</h4> Tumor necrosis factor-α (TNF-α) is an important mediator of the immune response. At present, the improvement of TNF-α after continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) is still controversial. <h4>Methods</h4> We conducted a systematic review of the present evidence based on a meta-analysis to elucidate the effects of TNF-α on OSAHS after CPAP treatment. <h4>Results</h4> To measure TNF-α, ten studies used enzyme-linked immunosorbent assay (ELISA), and one used radioimmunoassay. The forest plot outcome indicated that CPAP therapy would lower the TNF-α levels in OSAHS patients, with a weighted mean difference (WMD) of 1.08 (95% CI: 0.62–1.55; P < 0.001) based on the REM since there is highly significant heterogeneity (I2 = 90%) among the studies. Therefore, we used the subgroup and sensitivity analyses to investigate the source of heterogeneity. The findings of the sensitivity analysis revealed that the pooled WMD ranged from 0.91 (95% CI: 0.52–1.31; P < 0.001) to 1.18 (95% CI: 0.74–1.63; P < 0.001). The findings were not influenced by any single study. Notably, there was homogeneity in the Asia subgroup and publication year: 2019, implying that these subgroups could be the source of heterogeneity. <h4>Conclusion</h4> Our meta-analysis recommends that CPAP therapy will decrease the TNF-α level in OSAHS patients, but more related research should be conducted.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035913/?tool=EBI |
| spellingShingle | Yong Luo Fa-Rong Zhang Jun-Lin Wu Xi-Jiao Jiang Efficacy of continuous positive airway pressure on TNF-α in obstructive sleep apnea patients: A meta-analysis PLoS ONE |
| title | Efficacy of continuous positive airway pressure on TNF-α in obstructive sleep apnea patients: A meta-analysis |
| title_full | Efficacy of continuous positive airway pressure on TNF-α in obstructive sleep apnea patients: A meta-analysis |
| title_fullStr | Efficacy of continuous positive airway pressure on TNF-α in obstructive sleep apnea patients: A meta-analysis |
| title_full_unstemmed | Efficacy of continuous positive airway pressure on TNF-α in obstructive sleep apnea patients: A meta-analysis |
| title_short | Efficacy of continuous positive airway pressure on TNF-α in obstructive sleep apnea patients: A meta-analysis |
| title_sort | efficacy of continuous positive airway pressure on tnf α in obstructive sleep apnea patients a meta analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035913/?tool=EBI |
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