COMPARATIVE VALUATION OF HEPATOPROTECTIVE ACTIVITY OF FLAVONOIDS IN COURSE ALCOHOLIZATION OF RATS
Alcohol abuse is widespread and is a serious medical and social problem throughout the world especially in the USA and Europe countries including Russia. Alcohol influences negatively all organs. However liver is the most amenable to its action, because it is in liver where oxidation of ethanol take...
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| Format: | Article |
| Language: | Russian |
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Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute
2015-09-01
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| Series: | Фармация и фармакология (Пятигорск) |
| Subjects: | |
| Online Access: | https://www.pharmpharm.ru/jour/article/view/49 |
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| author | E. O. Sergeeva E. G. Dorkina L. A. Sadzhaya I. V. Skulte O. M. Sharenko I. M. Derevenets |
| author_facet | E. O. Sergeeva E. G. Dorkina L. A. Sadzhaya I. V. Skulte O. M. Sharenko I. M. Derevenets |
| author_sort | E. O. Sergeeva |
| collection | DOAJ |
| description | Alcohol abuse is widespread and is a serious medical and social problem throughout the world especially in the USA and Europe countries including Russia. Alcohol influences negatively all organs. However liver is the most amenable to its action, because it is in liver where oxidation of ethanol takes place. In the experiments on white outbreed female rats hepatoprotective action of medical and preventive application of diosmin and flavicin in comparison with quercetine by the capacity of biological indices of functional liver state normalization on the model of course alcoholization. We have established that flavicin at a dose of 100 mg/kg has the most signified hepatoprotective action. This is probably connected with high bioaccessibility of this compound which is provided by carbohydrate component and С2-С3 linking in diosmin molecule in the form of which this compound exhibits activity in vivo |
| first_indexed | 2024-04-10T01:36:46Z |
| format | Article |
| id | doaj.art-3d223a83ebfc462995ff69726147a5a2 |
| institution | Directory Open Access Journal |
| issn | 2307-9266 2413-2241 |
| language | Russian |
| last_indexed | 2025-03-14T08:59:45Z |
| publishDate | 2015-09-01 |
| publisher | Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute |
| record_format | Article |
| series | Фармация и фармакология (Пятигорск) |
| spelling | doaj.art-3d223a83ebfc462995ff69726147a5a22025-03-02T12:43:11ZrusVolgograd State Medical University, Pyatigorsk Medical and Pharmaceutical InstituteФармация и фармакология (Пятигорск)2307-92662413-22412015-09-0125(6)293410.19163/2307-9266-2014-2-5(6)-29-3449COMPARATIVE VALUATION OF HEPATOPROTECTIVE ACTIVITY OF FLAVONOIDS IN COURSE ALCOHOLIZATION OF RATSE. O. Sergeeva0E. G. Dorkina1L. A. Sadzhaya2I. V. Skulte3O. M. Sharenko4I. M. Derevenets5Pyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical UniversityPyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical UniversityPyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical UniversityPyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical UniversityPyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical UniversityPyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical UniversityAlcohol abuse is widespread and is a serious medical and social problem throughout the world especially in the USA and Europe countries including Russia. Alcohol influences negatively all organs. However liver is the most amenable to its action, because it is in liver where oxidation of ethanol takes place. In the experiments on white outbreed female rats hepatoprotective action of medical and preventive application of diosmin and flavicin in comparison with quercetine by the capacity of biological indices of functional liver state normalization on the model of course alcoholization. We have established that flavicin at a dose of 100 mg/kg has the most signified hepatoprotective action. This is probably connected with high bioaccessibility of this compound which is provided by carbohydrate component and С2-С3 linking in diosmin molecule in the form of which this compound exhibits activity in vivohttps://www.pharmpharm.ru/jour/article/view/49flavonidshepatoprotective actionalcohol. |
| spellingShingle | E. O. Sergeeva E. G. Dorkina L. A. Sadzhaya I. V. Skulte O. M. Sharenko I. M. Derevenets COMPARATIVE VALUATION OF HEPATOPROTECTIVE ACTIVITY OF FLAVONOIDS IN COURSE ALCOHOLIZATION OF RATS Фармация и фармакология (Пятигорск) flavonids hepatoprotective action alcohol. |
| title | COMPARATIVE VALUATION OF HEPATOPROTECTIVE ACTIVITY OF FLAVONOIDS IN COURSE ALCOHOLIZATION OF RATS |
| title_full | COMPARATIVE VALUATION OF HEPATOPROTECTIVE ACTIVITY OF FLAVONOIDS IN COURSE ALCOHOLIZATION OF RATS |
| title_fullStr | COMPARATIVE VALUATION OF HEPATOPROTECTIVE ACTIVITY OF FLAVONOIDS IN COURSE ALCOHOLIZATION OF RATS |
| title_full_unstemmed | COMPARATIVE VALUATION OF HEPATOPROTECTIVE ACTIVITY OF FLAVONOIDS IN COURSE ALCOHOLIZATION OF RATS |
| title_short | COMPARATIVE VALUATION OF HEPATOPROTECTIVE ACTIVITY OF FLAVONOIDS IN COURSE ALCOHOLIZATION OF RATS |
| title_sort | comparative valuation of hepatoprotective activity of flavonoids in course alcoholization of rats |
| topic | flavonids hepatoprotective action alcohol. |
| url | https://www.pharmpharm.ru/jour/article/view/49 |
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