Mismatch Repair System Genomic Scars in Gastroesophageal Cancers: Biology and Clinical Testing
Alterations in the mismatch repair (MMR) system result in genomic instability, neoantigen production, and immune response in cancer. There is evidence that gastroesophageal tumors with MMR deficiency may be susceptible to immune-checkpoint inhibitors treatment, especially in those presenting at adva...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
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| Series: | Gastrointestinal Disorders |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-5647/2/4/31 |