Gene Duplications in the Genomes of Staphylococci and Enterococci
Gene duplications are a feature of bacterial genomes. In the present work we analyze the extent of gene duplications in the genomes of three microorganisms that belong to the Firmicutes phylum and that are etiologic agents of several nosocomial infections: Staphylococcus aureus, Enterococcus faecium...
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmolb.2020.00160/full |
| _version_ | 1831634781442408448 |
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| author | José Francisco Sanchez-Herrero José Francisco Sanchez-Herrero José Francisco Sanchez-Herrero Manuel Bernabeu Alejandro Prieto Mário Hüttener Antonio Juárez Antonio Juárez |
| author_facet | José Francisco Sanchez-Herrero José Francisco Sanchez-Herrero José Francisco Sanchez-Herrero Manuel Bernabeu Alejandro Prieto Mário Hüttener Antonio Juárez Antonio Juárez |
| author_sort | José Francisco Sanchez-Herrero |
| collection | DOAJ |
| description | Gene duplications are a feature of bacterial genomes. In the present work we analyze the extent of gene duplications in the genomes of three microorganisms that belong to the Firmicutes phylum and that are etiologic agents of several nosocomial infections: Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis. In all three groups, there is an irregular distribution of duplications in the genomes of the strains analyzed. Whereas in some of the strains duplications are scarce, hundreds of duplications are present in others. In all three species, mobile DNA accounts for a large percentage of the duplicated genes: phage DNA in S. aureus, and plasmid DNA in the enterococci. Duplicates also include core genes. In all three species, a reduced group of genes is duplicated in all strains analyzed. Duplication of the deoC and rpmG genes is a hallmark of S. aureus genomes. Duplication of the gene encoding the PTS IIB subunit is detected in all enterococci genomes. In E. faecalis it is remarkable that the genomes of some strains encode duplicates of the prgB and prgU genes. They belong to the prgABCU cluster, which responds to the presence of the peptide pheromone cCF10 by expressing the surface adhesins PrgA, PrgB, and PrgC. |
| first_indexed | 2024-12-19T06:01:11Z |
| format | Article |
| id | doaj.art-3d23fe9a485647379fa8cf3a7e5c96f3 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-19T06:01:11Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-3d23fe9a485647379fa8cf3a7e5c96f32022-12-21T20:33:18ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2020-07-01710.3389/fmolb.2020.00160563678Gene Duplications in the Genomes of Staphylococci and EnterococciJosé Francisco Sanchez-Herrero0José Francisco Sanchez-Herrero1José Francisco Sanchez-Herrero2Manuel Bernabeu3Alejandro Prieto4Mário Hüttener5Antonio Juárez6Antonio Juárez7Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, SpainBiodiversity Research Institute (IRBio), University of Barcelona, Barcelona, SpainHigh Content Genomics and Bioinformatics Unit, Germans Trias i Pujol Research Institute (IGTP), Campus Can Ruti, Badalona, SpainDepartment of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, SpainDepartment of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, SpainDepartment of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, SpainDepartment of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, SpainInstitute for Bioengineering of Catalonia, The Barcelona Institute of Science and Technology, Barcelona, SpainGene duplications are a feature of bacterial genomes. In the present work we analyze the extent of gene duplications in the genomes of three microorganisms that belong to the Firmicutes phylum and that are etiologic agents of several nosocomial infections: Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis. In all three groups, there is an irregular distribution of duplications in the genomes of the strains analyzed. Whereas in some of the strains duplications are scarce, hundreds of duplications are present in others. In all three species, mobile DNA accounts for a large percentage of the duplicated genes: phage DNA in S. aureus, and plasmid DNA in the enterococci. Duplicates also include core genes. In all three species, a reduced group of genes is duplicated in all strains analyzed. Duplication of the deoC and rpmG genes is a hallmark of S. aureus genomes. Duplication of the gene encoding the PTS IIB subunit is detected in all enterococci genomes. In E. faecalis it is remarkable that the genomes of some strains encode duplicates of the prgB and prgU genes. They belong to the prgABCU cluster, which responds to the presence of the peptide pheromone cCF10 by expressing the surface adhesins PrgA, PrgB, and PrgC.https://www.frontiersin.org/article/10.3389/fmolb.2020.00160/fullgene duplicationStaphylococcus aureusEnterococcus faeciumEnterococcus faecalisbacterial genomics |
| spellingShingle | José Francisco Sanchez-Herrero José Francisco Sanchez-Herrero José Francisco Sanchez-Herrero Manuel Bernabeu Alejandro Prieto Mário Hüttener Antonio Juárez Antonio Juárez Gene Duplications in the Genomes of Staphylococci and Enterococci Frontiers in Molecular Biosciences gene duplication Staphylococcus aureus Enterococcus faecium Enterococcus faecalis bacterial genomics |
| title | Gene Duplications in the Genomes of Staphylococci and Enterococci |
| title_full | Gene Duplications in the Genomes of Staphylococci and Enterococci |
| title_fullStr | Gene Duplications in the Genomes of Staphylococci and Enterococci |
| title_full_unstemmed | Gene Duplications in the Genomes of Staphylococci and Enterococci |
| title_short | Gene Duplications in the Genomes of Staphylococci and Enterococci |
| title_sort | gene duplications in the genomes of staphylococci and enterococci |
| topic | gene duplication Staphylococcus aureus Enterococcus faecium Enterococcus faecalis bacterial genomics |
| url | https://www.frontiersin.org/article/10.3389/fmolb.2020.00160/full |
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