The interplay between NLRs and autophagy in immunity and inflammation
Since they were first described as cytosolic sensors of microbial molecules a decade ago, the Nod-like receptors (NLRs) have been shown to have many different and important roles in various aspects of immune and inflammatory responses, ranging from antimicrobial mechanisms to control of adaptive res...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00361/full |
| _version_ | 1818522579497910272 |
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| author | Leticia A. M Carneiro Leonardo H Travassos |
| author_facet | Leticia A. M Carneiro Leonardo H Travassos |
| author_sort | Leticia A. M Carneiro |
| collection | DOAJ |
| description | Since they were first described as cytosolic sensors of microbial molecules a decade ago, the Nod-like receptors (NLRs) have been shown to have many different and important roles in various aspects of immune and inflammatory responses, ranging from antimicrobial mechanisms to control of adaptive responses. In this review, we focus on the interplay between NLRs and autophagy, an evolutionarily conserved mechanism that is crucial for homeostasis and has recently been shown to be involved in the protective response against infections. Furthermore, the association between mutations of NLRs as well as proteins that form the autophagic machinery and inflammatory diseases such as Crohn’s disease highlight the importance of these proteins and their interactions in the regulation of inflammation. |
| first_indexed | 2024-12-11T05:35:10Z |
| format | Article |
| id | doaj.art-3d240e9d29114b1dac5f57c9222ab30b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T05:35:10Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3d240e9d29114b1dac5f57c9222ab30b2022-12-22T01:19:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-11-01410.3389/fimmu.2013.0036164567The interplay between NLRs and autophagy in immunity and inflammationLeticia A. M Carneiro0Leonardo H Travassos1Federal University of Rio de JaneiroInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de JaneiroSince they were first described as cytosolic sensors of microbial molecules a decade ago, the Nod-like receptors (NLRs) have been shown to have many different and important roles in various aspects of immune and inflammatory responses, ranging from antimicrobial mechanisms to control of adaptive responses. In this review, we focus on the interplay between NLRs and autophagy, an evolutionarily conserved mechanism that is crucial for homeostasis and has recently been shown to be involved in the protective response against infections. Furthermore, the association between mutations of NLRs as well as proteins that form the autophagic machinery and inflammatory diseases such as Crohn’s disease highlight the importance of these proteins and their interactions in the regulation of inflammation.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00361/fullAutophagyCrohn DiseaseInfectionInflammasomesInflammationinnate immunity |
| spellingShingle | Leticia A. M Carneiro Leonardo H Travassos The interplay between NLRs and autophagy in immunity and inflammation Frontiers in Immunology Autophagy Crohn Disease Infection Inflammasomes Inflammation innate immunity |
| title | The interplay between NLRs and autophagy in immunity and inflammation |
| title_full | The interplay between NLRs and autophagy in immunity and inflammation |
| title_fullStr | The interplay between NLRs and autophagy in immunity and inflammation |
| title_full_unstemmed | The interplay between NLRs and autophagy in immunity and inflammation |
| title_short | The interplay between NLRs and autophagy in immunity and inflammation |
| title_sort | interplay between nlrs and autophagy in immunity and inflammation |
| topic | Autophagy Crohn Disease Infection Inflammasomes Inflammation innate immunity |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00361/full |
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