Exploring antioxidant strategies in the pathogenesis of ALS
The central nervous system is essential for maintaining homeostasis and controlling the body’s physiological functions. However, its biochemical characteristics make it highly vulnerable to oxidative damage, which is a common factor in neurodegenerative diseases like amyotrophic lateral sclerosis (A...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2024-03-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2022-0842 |
| _version_ | 1797229642014261248 |
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| author | Pinilla-González Víctor Montecinos-Barrientos Benjamin Martin-Kommer Clemente Chichiarelli Silvia Saso Luciano Rodrigo Ramón |
| author_facet | Pinilla-González Víctor Montecinos-Barrientos Benjamin Martin-Kommer Clemente Chichiarelli Silvia Saso Luciano Rodrigo Ramón |
| author_sort | Pinilla-González Víctor |
| collection | DOAJ |
| description | The central nervous system is essential for maintaining homeostasis and controlling the body’s physiological functions. However, its biochemical characteristics make it highly vulnerable to oxidative damage, which is a common factor in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). ALS is a leading cause of motor neuron disease, characterized by a rapidly progressing and incurable condition. ALS often results in death from respiratory failure within 3–5 years from the onset of the first symptoms, underscoring the urgent need to address this medical challenge. The aim of this study is to present available data supporting the role of oxidative stress in the mechanisms underlying ALS and to discuss potential antioxidant therapies currently in development. These therapies aim to improve the quality of life and life expectancy for patients affected by this devastating disease. |
| first_indexed | 2024-04-24T15:15:50Z |
| format | Article |
| id | doaj.art-3d2706effc5f40449fdd9d3fcc0e6de1 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-24T15:15:50Z |
| publishDate | 2024-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-3d2706effc5f40449fdd9d3fcc0e6de12024-04-02T09:19:33ZengDe GruyterOpen Life Sciences2391-54122024-03-01191131710.1515/biol-2022-0842Exploring antioxidant strategies in the pathogenesis of ALSPinilla-González Víctor0Montecinos-Barrientos Benjamin1Martin-Kommer Clemente2Chichiarelli Silvia3Saso Luciano4Rodrigo Ramón5Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago8380000, ChileFaculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago8380000, ChileFaculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago8380000, ChileDepartment of Biochemical Sciences “A. Rossi-Fanelli”, Sapienza University of Rome, 00185Rome, ItalyDepartment of Physiology and Pharmacology “Vittorio Erspamer”, Faculty of Pharmacy and Medicine, Sapienza University, P.le Aldo Moro 5, 00185Rome, ItalyFaculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago8380000, ChileThe central nervous system is essential for maintaining homeostasis and controlling the body’s physiological functions. However, its biochemical characteristics make it highly vulnerable to oxidative damage, which is a common factor in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). ALS is a leading cause of motor neuron disease, characterized by a rapidly progressing and incurable condition. ALS often results in death from respiratory failure within 3–5 years from the onset of the first symptoms, underscoring the urgent need to address this medical challenge. The aim of this study is to present available data supporting the role of oxidative stress in the mechanisms underlying ALS and to discuss potential antioxidant therapies currently in development. These therapies aim to improve the quality of life and life expectancy for patients affected by this devastating disease.https://doi.org/10.1515/biol-2022-0842antioxidantsamyotrophic lateral sclerosisoxidative stressiron chelationmultitarget therapy |
| spellingShingle | Pinilla-González Víctor Montecinos-Barrientos Benjamin Martin-Kommer Clemente Chichiarelli Silvia Saso Luciano Rodrigo Ramón Exploring antioxidant strategies in the pathogenesis of ALS Open Life Sciences antioxidants amyotrophic lateral sclerosis oxidative stress iron chelation multitarget therapy |
| title | Exploring antioxidant strategies in the pathogenesis of ALS |
| title_full | Exploring antioxidant strategies in the pathogenesis of ALS |
| title_fullStr | Exploring antioxidant strategies in the pathogenesis of ALS |
| title_full_unstemmed | Exploring antioxidant strategies in the pathogenesis of ALS |
| title_short | Exploring antioxidant strategies in the pathogenesis of ALS |
| title_sort | exploring antioxidant strategies in the pathogenesis of als |
| topic | antioxidants amyotrophic lateral sclerosis oxidative stress iron chelation multitarget therapy |
| url | https://doi.org/10.1515/biol-2022-0842 |
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