Inferior petrosal sinus sampling in differential diagnosis of ACTH-dependent hypercortisolism
Survival rate of patients with endogenous hypercortisolism, as well as complications reversibility and treatment effectiveness depends on on-time and precise diagnosis. In case of apparent clinical picture with all laboratory tests confirmation, the most challenging appears the differential diagnosi...
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| Format: | Article |
| Language: | Russian |
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Endocrinology Research Centre
2018-08-01
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| Series: | Эндокринная хирургия |
| Subjects: | |
| Online Access: | https://surg-endojournals.ru/serg/article/viewFile/9752/7356 |
| _version_ | 1818576748663537664 |
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| author | Ivan I. Sitkin Anastasia A. Malygina Zhanna E. Belaya Lyudmila Y. Rozhinskaya Svetlana A. Buryakina |
| author_facet | Ivan I. Sitkin Anastasia A. Malygina Zhanna E. Belaya Lyudmila Y. Rozhinskaya Svetlana A. Buryakina |
| author_sort | Ivan I. Sitkin |
| collection | DOAJ |
| description | Survival rate of patients with endogenous hypercortisolism, as well as complications reversibility and treatment effectiveness depends on on-time and precise diagnosis. In case of apparent clinical picture with all laboratory tests confirmation, the most challenging appears the differential diagnosis of ACTH-dependent hypercortisolism as none laboratory test can reveal the genesis of ACTH hypersecretion. When there is no visualization of the pituitary adenoma, the only method to confirm the diagnosis is bilateral inferior petrosal sinus sampling (BIPSS). Nevertheless, around 16% of patients have inactive pituitary incidentalomas in combination with carcinoid tumor of other localization. Epidemiologic researches show that the size of such incidentalomas tend to be less than 6 mm. According to clinical guidelines in case of such small neoplasms its recommended to perform bilateral inferior petrosal sinus sampling. This clinical case represent a rare exception to the rules when there is a pituitary adenoma more than 6 mm and mild hypercortisolism, possibly as the result of lung carcinoid tumor. |
| first_indexed | 2024-12-16T06:18:57Z |
| format | Article |
| id | doaj.art-3d275f0bbccf4f91a40d55ab8e1605bc |
| institution | Directory Open Access Journal |
| issn | 2306-3513 2310-3965 |
| language | Russian |
| last_indexed | 2024-12-16T06:18:57Z |
| publishDate | 2018-08-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Эндокринная хирургия |
| spelling | doaj.art-3d275f0bbccf4f91a40d55ab8e1605bc2022-12-21T22:41:12ZrusEndocrinology Research CentreЭндокринная хирургия2306-35132310-39652018-08-01122899510.14341/serg97528533Inferior petrosal sinus sampling in differential diagnosis of ACTH-dependent hypercortisolismIvan I. Sitkin0Anastasia A. Malygina1Zhanna E. Belaya2Lyudmila Y. Rozhinskaya3Svetlana A. Buryakina4Endocrinology Research Centre, Moscow, RussiaEndocrinology Research Centre, Moscow, RussiaEndocrinology Research Centre, Moscow, RussiaEndocrinology Research CentreEndocrinology Research CentreSurvival rate of patients with endogenous hypercortisolism, as well as complications reversibility and treatment effectiveness depends on on-time and precise diagnosis. In case of apparent clinical picture with all laboratory tests confirmation, the most challenging appears the differential diagnosis of ACTH-dependent hypercortisolism as none laboratory test can reveal the genesis of ACTH hypersecretion. When there is no visualization of the pituitary adenoma, the only method to confirm the diagnosis is bilateral inferior petrosal sinus sampling (BIPSS). Nevertheless, around 16% of patients have inactive pituitary incidentalomas in combination with carcinoid tumor of other localization. Epidemiologic researches show that the size of such incidentalomas tend to be less than 6 mm. According to clinical guidelines in case of such small neoplasms its recommended to perform bilateral inferior petrosal sinus sampling. This clinical case represent a rare exception to the rules when there is a pituitary adenoma more than 6 mm and mild hypercortisolism, possibly as the result of lung carcinoid tumor.https://surg-endojournals.ru/serg/article/viewFile/9752/7356cushing syndrome, ectopic acth syndrome, inferior petrosal sinus sampling, clinical case |
| spellingShingle | Ivan I. Sitkin Anastasia A. Malygina Zhanna E. Belaya Lyudmila Y. Rozhinskaya Svetlana A. Buryakina Inferior petrosal sinus sampling in differential diagnosis of ACTH-dependent hypercortisolism Эндокринная хирургия cushing syndrome, ectopic acth syndrome, inferior petrosal sinus sampling, clinical case |
| title | Inferior petrosal sinus sampling in differential diagnosis of ACTH-dependent hypercortisolism |
| title_full | Inferior petrosal sinus sampling in differential diagnosis of ACTH-dependent hypercortisolism |
| title_fullStr | Inferior petrosal sinus sampling in differential diagnosis of ACTH-dependent hypercortisolism |
| title_full_unstemmed | Inferior petrosal sinus sampling in differential diagnosis of ACTH-dependent hypercortisolism |
| title_short | Inferior petrosal sinus sampling in differential diagnosis of ACTH-dependent hypercortisolism |
| title_sort | inferior petrosal sinus sampling in differential diagnosis of acth dependent hypercortisolism |
| topic | cushing syndrome, ectopic acth syndrome, inferior petrosal sinus sampling, clinical case |
| url | https://surg-endojournals.ru/serg/article/viewFile/9752/7356 |
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