Investigation of the Uptake and Transport of Aspirin Eugenol Ester in the Caco-2 Cell Model

Investigation of the Uptake and Transport of Aspirin Eugenol Ester in the Caco-2 Cell Model

Background: Aspirin eugenol ester (AEE) is a novel medicinal compound synthesized by esterification of aspirin with eugenol using the prodrug principle. AEE has the pharmacological activities of being anti-inflammatory, antipyretic, analgesic, anti-cardiovascular diseases, and anti-oxidative stress...

Full description

Bibliographic Details
Main Authors:	Qi Tao, Zhe Qin, Xi-Wang Liu, Zhen-Dong Zhang, Shi-Hong Li, Li-Xia Bai, Jian-Yong Li, Ya-Jun Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Series:	Frontiers in Pharmacology
Subjects:	aspirin eugenol ester salicylic acid Caco-2 cells uptake transport
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.887598/full

Similar Items

Multi-omics reveals aspirin eugenol ester alleviates neurological disease
by: Qi Tao, et al.
Published: (2023-10-01)

Aspirin Eugenol Ester Attenuates Paraquat-Induced Hepatotoxicity by Inhibiting Oxidative Stress
by: Zhen-Dong Zhang, et al.
Published: (2020-10-01)

Untargeted lipidomics and metagenomics reveal the mechanism of aspirin eugenol ester relieving hyperlipidemia in ApoE−/− mice
by: Xiao-Rong Lu, et al.
Published: (2022-12-01)

Aspirin eugenol ester alleviates lipopolysaccharide-induced acute lung injury in rats while stabilizing serum metabolites levels
by: Qi Tao, et al.
Published: (2022-07-01)

Multi-Omics Approaches for Liver Reveal the Thromboprophylaxis Mechanism of Aspirin Eugenol Ester in Rat Thrombosis Model
by: Qi Tao, et al.
Published: (2024-02-01)

Protective Effect and Mechanism of Aspirin Eugenol Ester on Lipopolysaccharide-Induced Intestinal Barrier Injury
by: Qi Tao, et al.
Published: (2023-12-01)

Effects of Aspirin Eugenol Ester on Liver Oxidative Damage and Energy Metabolism in Immune-Stressed Broilers
by: Jiale Zhong, et al.
Published: (2024-03-01)

Aspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia
by: Ning Ma, et al.
Published: (2018-12-01)

Aspirin Eugenol Ester Protects Vascular Endothelium From Oxidative Injury by the Apoptosis Signal Regulating Kinase-1 Pathway
by: Mei-Zhou Huang, et al.
Published: (2020-11-01)

Feces and liver tissue metabonomics studies on the regulatory effect of aspirin eugenol eater in hyperlipidemic rats
by: Ning Ma, et al.
Published: (2017-12-01)

The Protective Effect of Aspirin Eugenol Ester on Paraquat-Induced Acute Liver Injury Rats
by: Zhen-Dong Zhang, et al.
Published: (2020-12-01)

Aspirin eugenol ester ameliorates LPS-induced inflammatory responses in RAW264.7 cells and mice
by: Xu Liu, et al.
Published: (2023-08-01)

The Transport and Uptake of Resveratrol Mediated via Glucose Transporter 1 and Its Antioxidant Effect in Caco-2 Cells
by: Zhen-Dong Zhang, et al.
Published: (2023-06-01)

Biological Evaluation of Natural and Synthesized Homovanillic Acid Esters as Inhibitors of Intestinal Fatty Acid Uptake in Differentiated Caco-2 Cells
by: Barbara Lieder, et al.
Published: (2019-10-01)

A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE-/- mice
by: Xiao-Rong Lu, et al.
Published: (2024-04-01)

AEE alleviates ox-LDL-induced lipid accumulation and inflammation in macrophages
by: Ya-Xian Liu, et al.
Published: (2023-11-01)

Enhancement of the antioxidant and skin permeation properties of eugenol by the esterification of eugenol to new derivatives
by: Edyta Makuch, et al.
Published: (2020-10-01)

Synthesis, Insecticidal Activity and Computational Studies of Eugenol-Based Insecticides
by: José Ricardo A. Coelho, et al.
Published: (2022-11-01)

Inhibitory Influence of Panax notoginseng Saponins on Aspirin Hydrolysis in Human Intestinal Caco-2 Cells
by: Zongxi Sun, et al.
Published: (2018-02-01)

Spermidine-Eugenol Supplement Preserved Inflammation-Challenged Intestinal Cells by Stimulating Autophagy
by: Francesca Truzzi, et al.
Published: (2023-02-01)

UPLC-Q-TOF/MS-Based Plasma Metabolomics to Evaluate the Effects of Aspirin Eugenol Ester on Blood Stasis in Rats
by: Dongshuai Shen, et al.
Published: (2019-06-01)

The transport mechanism of monocarboxylate transporter on spinosin in Caco-2 cells
by: Xiang Le Meng, et al.
Published: (2016-05-01)

Eugenol Ester Derivatives: Synthesis, Insecticidal Activity and Computational Studies
by: José R. A. Coelho, et al.
Published: (2021-11-01)

Effects of 6-Shogaol on Glucose Uptake and Intestinal Barrier Integrity in Caco-2 Cells
by: Wenya Jiao, et al.
Published: (2023-01-01)

Synthesis, Anti-Tyrosinase Activity, and Spectroscopic Inhibition Mechanism of Cinnamic Acid–Eugenol Esters
by: Jianping Li, et al.
Published: (2023-08-01)

Uptake and Immunomodulatory Properties of Betanin, Vulgaxanthin I and Indicaxanthin towards Caco-2 Intestinal Cells
by: Yunqing Wang, et al.
Published: (2022-08-01)

Sintesis Metil Eugenol dan Benzil Eugenol dari Minyak Daun Cengkeh
by: Ngadiwiyana Ngadiwiyana, et al.
Published: (2004-12-01)

Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis
by: Hossein Esmaeilzadeh, et al.
Published: (2017-03-01)

Aspirin Induces Mitochondrial Ca<sup>2+</sup> Remodeling in Tumor Cells via ROS‒Depolarization‒Voltage-Gated Ca<sup>2+</sup> Entry
by: Itsuho Fujikawa, et al.
Published: (2020-07-01)

The Intake of Coffee Increases the Absorption of Aspirin in Mice by Modifying Gut Microbiome
by: Jeon-Kyung Kim, et al.
Published: (2022-03-01)

Uptake and Transport of Naringenin and Its Antioxidant Effects in Human Intestinal Epithelial Caco-2 Cells
by: Zhen-Dong Zhang, et al.
Published: (2022-05-01)

Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II
by: Jacob Andring, et al.
Published: (2020-03-01)

Aspirin in COVID-19: Pros and Cons
by: Rana Zareef, et al.
Published: (2022-03-01)

Low uptake of silica nanoparticles in Caco-2 intestinal epithelial barriers
by: Dong Ye, et al.
Published: (2017-07-01)

Pemisahan eugenol daripada eugenia Caryophyllata dan kajian beberapa tindak balas eugenol /
by: 184275 Tew, Siew Yoke
Published: (2001)

Determination of Acetyl Salicylic Acid in Aspirin tablets
by: Lana Mohammed Ali, et al.
Published: (2019-12-01)

Investigations of eugenol efficacy in treatment of mange in swine
by: Jezdimirović Milanka, et al.
Published: (2006-01-01)

Antioxidant capacity of eugenol derivatives
by: María E. Hidalgo, et al.
Published: (2009-01-01)

Colorimetric Detection of Salicylic Acid in Aspirin Using MIL-53(Fe) Nanozyme
by: Ling Liang, et al.
Published: (2020-09-01)

Polimerisasi Eugenol Dengan Katalis Asam Sulfat Pekat
by: Ngadiwiyana Ngadiwiyana
Published: (2005-08-01)