Impact of Low-Dose Methotrexate–Adalimumab Combination Therapy on the Antibody Response Induced by the mRNA-1273 SARS-CoV-2 Vaccine: Case of an Elderly Patient with Rheumatoid Arthritis
Patients with rheumatoid arthritis (RA) are treated with drugs that may impact their immune responses to SARS-CoV-2 vaccines. We describe here the anti-Spike (anti-S) IgG and neutralizing antibody responses induced by the mRNA-1273 SARS-CoV-2 vaccine in a 78-years-old patient with RA, who received a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/8/883 |
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| author | Yves Michiels Nadhira Houhou-Fidouh Gilles Collin Jérôme Berger Evelyne Kohli |
| author_facet | Yves Michiels Nadhira Houhou-Fidouh Gilles Collin Jérôme Berger Evelyne Kohli |
| author_sort | Yves Michiels |
| collection | DOAJ |
| description | Patients with rheumatoid arthritis (RA) are treated with drugs that may impact their immune responses to SARS-CoV-2 vaccines. We describe here the anti-Spike (anti-S) IgG and neutralizing antibody responses induced by the mRNA-1273 SARS-CoV-2 vaccine in a 78-years-old patient with RA, who received a low-dose combination therapy of methotrexate and adalimumab, shortly before vaccine administration. Both near-normal and impaired immune responses to vaccines have been reported previously in patients treated with these drugs. Our case report shows that, even at low doses, combined methotrexate-adalimumab therapy can be associated with a weak immune response to the mRNA1273 vaccine in elderly patients. |
| first_indexed | 2024-03-10T08:18:25Z |
| format | Article |
| id | doaj.art-3d294ffe9b824e7b943339c29dbd09bf |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T08:18:25Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-3d294ffe9b824e7b943339c29dbd09bf2023-11-22T10:07:25ZengMDPI AGVaccines2076-393X2021-08-019888310.3390/vaccines9080883Impact of Low-Dose Methotrexate–Adalimumab Combination Therapy on the Antibody Response Induced by the mRNA-1273 SARS-CoV-2 Vaccine: Case of an Elderly Patient with Rheumatoid ArthritisYves Michiels0Nadhira Houhou-Fidouh1Gilles Collin2Jérôme Berger3Evelyne Kohli4Community Pharmacy, Center for Primary Care and Public Health (Unisanté) Lausanne 1011, University of Lausanne, 1015 Lausanne, SwitzerlandLaboratoire de Virologie, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP-HP, 75018 Paris, FranceLaboratoire de Virologie, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP-HP, 75018 Paris, FranceCommunity Pharmacy, Center for Primary Care and Public Health (Unisanté) Lausanne 1011, University of Lausanne, 1015 Lausanne, SwitzerlandUMR INSERM/uB/AGROSUP 1231, Team 3 HSP-Pathies, Labellisée Ligue Nationale Contre le Cancer and Laboratoire d’Excellence LipSTIC, 21000 Dijon, FrancePatients with rheumatoid arthritis (RA) are treated with drugs that may impact their immune responses to SARS-CoV-2 vaccines. We describe here the anti-Spike (anti-S) IgG and neutralizing antibody responses induced by the mRNA-1273 SARS-CoV-2 vaccine in a 78-years-old patient with RA, who received a low-dose combination therapy of methotrexate and adalimumab, shortly before vaccine administration. Both near-normal and impaired immune responses to vaccines have been reported previously in patients treated with these drugs. Our case report shows that, even at low doses, combined methotrexate-adalimumab therapy can be associated with a weak immune response to the mRNA1273 vaccine in elderly patients.https://www.mdpi.com/2076-393X/9/8/883SARS-CoV-2mRNA1273 vaccineantibody responsemethotrexateadalimumab |
| spellingShingle | Yves Michiels Nadhira Houhou-Fidouh Gilles Collin Jérôme Berger Evelyne Kohli Impact of Low-Dose Methotrexate–Adalimumab Combination Therapy on the Antibody Response Induced by the mRNA-1273 SARS-CoV-2 Vaccine: Case of an Elderly Patient with Rheumatoid Arthritis Vaccines SARS-CoV-2 mRNA1273 vaccine antibody response methotrexate adalimumab |
| title | Impact of Low-Dose Methotrexate–Adalimumab Combination Therapy on the Antibody Response Induced by the mRNA-1273 SARS-CoV-2 Vaccine: Case of an Elderly Patient with Rheumatoid Arthritis |
| title_full | Impact of Low-Dose Methotrexate–Adalimumab Combination Therapy on the Antibody Response Induced by the mRNA-1273 SARS-CoV-2 Vaccine: Case of an Elderly Patient with Rheumatoid Arthritis |
| title_fullStr | Impact of Low-Dose Methotrexate–Adalimumab Combination Therapy on the Antibody Response Induced by the mRNA-1273 SARS-CoV-2 Vaccine: Case of an Elderly Patient with Rheumatoid Arthritis |
| title_full_unstemmed | Impact of Low-Dose Methotrexate–Adalimumab Combination Therapy on the Antibody Response Induced by the mRNA-1273 SARS-CoV-2 Vaccine: Case of an Elderly Patient with Rheumatoid Arthritis |
| title_short | Impact of Low-Dose Methotrexate–Adalimumab Combination Therapy on the Antibody Response Induced by the mRNA-1273 SARS-CoV-2 Vaccine: Case of an Elderly Patient with Rheumatoid Arthritis |
| title_sort | impact of low dose methotrexate adalimumab combination therapy on the antibody response induced by the mrna 1273 sars cov 2 vaccine case of an elderly patient with rheumatoid arthritis |
| topic | SARS-CoV-2 mRNA1273 vaccine antibody response methotrexate adalimumab |
| url | https://www.mdpi.com/2076-393X/9/8/883 |
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