Nuciferine attenuates the progression of osteoarthritis by targeting PI3K/Akt/NF-κB signaling pathway

Nuciferine attenuates the progression of osteoarthritis by targeting PI3K/Akt/NF-κB signaling pathway

Osteoarthritis (OA), a chronic disease featured by severe pain and persistent inflammation, significantly affects human health and lowers the quality of life. Nuciferine (Nuf) is major alkaloids abundant in lotus leaf and has various biological activities. In current study, we aimed to explored the...

Full description

Bibliographic Details
Main Authors:	Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Format:	Article
Language:	English
Published:	Elsevier 2021-11-01
Series:	Journal of Functional Foods
Subjects:	Osteoarthritis Nuciferine Chondrocytes Inflammation NF-κB PI3K
Online Access:	http://www.sciencedirect.com/science/article/pii/S1756464621003315

Similar Items

Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis
by: Shuangshuo Jia, et al.
Published: (2022-03-01)

Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
by: Taku Saito, et al.
Published: (2017-05-01)

Hyperoside attenuates osteoarthritis progression by targeting PI3K/Akt/NF-κB signaling pathway: In vitro and in vivo studies
by: Yang Yang, et al.
Published: (2022-08-01)

Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway
by: Minjun Yao, et al.
Published: (2022-06-01)

Nuciferine reduces vascular leakage and improves cardiac function in acute myocardial infarction by regulating the PI3K/AKT pathway
by: Wei Xie, et al.
Published: (2024-03-01)

Scutellarin ameliorates osteoarthritis by protecting chondrocytes and subchondral bone microstructure by inactivating NF-κB/MAPK signal transduction
by: Huan Yang, et al.
Published: (2022-11-01)

Syringic acid (SA) inhibits the IL-1β-induced inflammation in mice chondrocytes and ameliorates the progression of osteoarthritis via the PTEN/AKT/NF-κB pathway
by: Yao Li, et al.
Published: (2023-08-01)

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice
by: Zeng Lin, et al.
Published: (2019-05-01)

NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction
by: Moon-Chang Choi, et al.
Published: (2019-07-01)

Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis
by: Haitao Chen, et al.
Published: (2023-01-01)

Platelet-rich plasma inhibits Adriamycin-induced inflammation via blocking the NF-κB pathway in articular chondrocytes
by: Haijun Zhao, et al.
Published: (2021-06-01)

Nuciferine prevents hepatic steatosis associated with improving intestinal mucosal integrity, mucus-related microbiota and inhibiting TLR4/MyD88/NF-κB pathway in high-fat induced rats
by: Jiemin Fan, et al.
Published: (2022-01-01)

Sakuranetin reduces inflammation and chondrocyte dysfunction in osteoarthritis by inhibiting the PI3K/AKT/NF-κB pathway
by: Xiaofeng Deng, et al.
Published: (2024-02-01)

Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt
by: Cheol Park, et al.
Published: (2018-08-01)

The protective effect of kirenol in osteoarthritis: an in vitro and in vivo study
by: Wei Hu, et al.
Published: (2022-04-01)

Obeticholic Acid Derivative, T-2054 Suppresses Osteoarthritis via Inhibiting NF-κB-Signaling Pathway
by: Dandan Guo, et al.
Published: (2021-04-01)

Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway
by: Jia Y, et al.
Published: (2020-03-01)

κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway
by: Shi Yi, et al.
Published: (2023-11-01)

Complex Systems Biology Approach in Connecting PI3K-Akt and NF-κB Pathways in Prostate Cancer
by: Eswar Shankar, et al.
Published: (2019-02-01)

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways
by: Ran J, et al.
Published: (2018-05-01)

PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies
by: Ying Liu, et al.
Published: (2017-01-01)

Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K/Akt/NF-κB Signaling Pathway
by: Wenjun Li, et al.
Published: (2020-02-01)

Nuciferine reduced fat deposition by controlling triglyceride and cholesterol concentration in broiler chickens
by: Yingying Zhou, et al.
Published: (2020-12-01)

Clock gene Per1 regulates rat temporomandibular osteoarthritis through NF-κB pathway: an in vitro and in vivo study
by: Jia-ming Wei, et al.
Published: (2023-10-01)

Lentinan Inhibits AGE-Induced Inflammation and the Expression of Matrix-Degrading Enzymes in Human Chondrocytes
by: Zhang Z, et al.
Published: (2020-07-01)

Nuciferine improves cardiac function in mice subjected to myocardial ischemia/reperfusion injury by upregulating PPAR-γ
by: Ruisha Li, et al.
Published: (2023-02-01)

NCOA3 Loss Disrupts Molecular Signature of Chondrocytes and Promotes Posttraumatic Osteoarthritis Progression
by: Bing Zhang, et al.
Published: (2018-09-01)

Non-weight-bearing exercise attenuates papain-induced knee osteoarthritis in rats via the TLR4/MyD88/NF-κB signaling pathway
by: Kewen Wang, et al.
Published: (2023-09-01)

Betulin Alleviates the Inflammatory Response in Mouse Chondrocytes and Ameliorates Osteoarthritis via AKT/Nrf2/HO-1/NF-κB Axis
by: Chenghao Ren, et al.
Published: (2021-10-01)

Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway
by: Zizhuo Li, et al.
Published: (2019-03-01)

Scutellarin Attenuates the IL-1β-Induced Inflammation in Mouse Chondrocytes and Prevents Osteoarthritic Progression
by: Zucheng Luo, et al.
Published: (2020-02-01)

Study on the vasodilatory activity of lotus leaf extract and its representative substance nuciferine on thoracic aorta in rats
by: Hao Deng, et al.
Published: (2022-10-01)

Schisandrol A Suppresses Catabolic Factor Expression by Blocking NF-κB Signaling in Osteoarthritis
by: Seong Jae Han, et al.
Published: (2021-03-01)

Physicochemical Characterization and in Vivo Hypolipidemic Effect of Chitosan-Coated Nuciferine Liposomes
by: Rongrong WANG, et al.
Published: (2023-04-01)

PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics
by: Alia Ghoneum, et al.
Published: (2019-07-01)

Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases
by: Tong Zhao, et al.
Published: (2023-07-01)

Nuciferine Inhibits Proinflammatory Cytokines via the PPARs in LPS-Induced RAW264.7 Cells
by: Chao Zhang, et al.
Published: (2018-10-01)

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo
by: Zengxin Jiang, et al.
Published: (2022-09-01)

Asiatic acid affects the growth of human osteosarcoma cells by regulating PI3K/AKT and NF-κB dual signal pathways
by: Yanran Huang, et al.
Published: (2023-12-01)

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway
by: Yongjun Ye, et al.
Published: (2023-03-01)