Emerging advances in hydrogel-based therapeutic strategies for tissue regeneration
Significant developments in cell therapy and biomaterial science have broadened the therapeutic landscape of tissue regeneration. Tissue damage is a complex biological process in which different types of cells play a specific role in repairing damaged tissues and growth factors strictly regulate the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320423000895 |
| _version_ | 1797448039341752320 |
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| author | Wenqi Li Jing Hu Cheng Chen Xinyue Li Honghua Zhang Yanru Xin Qingchang Tian Shuling Wang |
| author_facet | Wenqi Li Jing Hu Cheng Chen Xinyue Li Honghua Zhang Yanru Xin Qingchang Tian Shuling Wang |
| author_sort | Wenqi Li |
| collection | DOAJ |
| description | Significant developments in cell therapy and biomaterial science have broadened the therapeutic landscape of tissue regeneration. Tissue damage is a complex biological process in which different types of cells play a specific role in repairing damaged tissues and growth factors strictly regulate the activity of these cells. Hydrogels have become promising biomaterials for tissue regeneration if appropriate materials are selected and the hydrogel properties are well-regulated. Importantly, they can be used as carriers for living cells and growth factors due to the high water-holding capacity, high permeability, and good biocompatibility of hydrogels. Cell-loaded hydrogels can play an essential role in treating damaged tissues and open new avenues for cell therapy. There is ample evidence substantiating the ability of hydrogels to facilitate the delivery of cells (stem cell, macrophage, chondrocyte, and osteoblast) and growth factors (bone morphogenetic protein, transforming growth factor, vascular endothelial growth factor and fibroblast growth factor). This paper reviewed the latest advances in hydrogels loaded with cells or growth factors to promote the reconstruction of tissues. Furthermore, we discussed the shortcomings of the application of hydrogels in tissue engineering to promote their further development. |
| first_indexed | 2024-03-09T14:04:38Z |
| format | Article |
| id | doaj.art-3d2adc312ddc41868f6e9f360b07be92 |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-03-09T14:04:38Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-3d2adc312ddc41868f6e9f360b07be922023-11-30T05:07:52ZengElsevierRegenerative Therapy2352-32042023-12-0124459471Emerging advances in hydrogel-based therapeutic strategies for tissue regenerationWenqi Li0Jing Hu1Cheng Chen2Xinyue Li3Honghua Zhang4Yanru Xin5Qingchang Tian6Shuling Wang7School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Corresponding author. School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Corresponding author. School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.Significant developments in cell therapy and biomaterial science have broadened the therapeutic landscape of tissue regeneration. Tissue damage is a complex biological process in which different types of cells play a specific role in repairing damaged tissues and growth factors strictly regulate the activity of these cells. Hydrogels have become promising biomaterials for tissue regeneration if appropriate materials are selected and the hydrogel properties are well-regulated. Importantly, they can be used as carriers for living cells and growth factors due to the high water-holding capacity, high permeability, and good biocompatibility of hydrogels. Cell-loaded hydrogels can play an essential role in treating damaged tissues and open new avenues for cell therapy. There is ample evidence substantiating the ability of hydrogels to facilitate the delivery of cells (stem cell, macrophage, chondrocyte, and osteoblast) and growth factors (bone morphogenetic protein, transforming growth factor, vascular endothelial growth factor and fibroblast growth factor). This paper reviewed the latest advances in hydrogels loaded with cells or growth factors to promote the reconstruction of tissues. Furthermore, we discussed the shortcomings of the application of hydrogels in tissue engineering to promote their further development.http://www.sciencedirect.com/science/article/pii/S2352320423000895HydrogelTissue engineeringCells therapiesGrowth factors3D-bioprinting |
| spellingShingle | Wenqi Li Jing Hu Cheng Chen Xinyue Li Honghua Zhang Yanru Xin Qingchang Tian Shuling Wang Emerging advances in hydrogel-based therapeutic strategies for tissue regeneration Regenerative Therapy Hydrogel Tissue engineering Cells therapies Growth factors 3D-bioprinting |
| title | Emerging advances in hydrogel-based therapeutic strategies for tissue regeneration |
| title_full | Emerging advances in hydrogel-based therapeutic strategies for tissue regeneration |
| title_fullStr | Emerging advances in hydrogel-based therapeutic strategies for tissue regeneration |
| title_full_unstemmed | Emerging advances in hydrogel-based therapeutic strategies for tissue regeneration |
| title_short | Emerging advances in hydrogel-based therapeutic strategies for tissue regeneration |
| title_sort | emerging advances in hydrogel based therapeutic strategies for tissue regeneration |
| topic | Hydrogel Tissue engineering Cells therapies Growth factors 3D-bioprinting |
| url | http://www.sciencedirect.com/science/article/pii/S2352320423000895 |
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