Exploring Pyrrolo-Fused Heterocycles as Promising Anticancer Agents: An Integrated Synthetic, Biological, and Computational Approach

Exploring Pyrrolo-Fused Heterocycles as Promising Anticancer Agents: An Integrated Synthetic, Biological, and Computational Approach

Five new series of pyrrolo-fused heterocycles were designed through a scaffold hybridization strategy as analogs of the well-known microtubule inhibitor phenstatin. Compounds were synthesized using the 1,3-dipolar cycloaddition of cycloimmonium N-ylides to ethyl propiolate as a key step. Selected co...

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Bibliographic Details
Main Authors:	Roxana-Maria Amărandi, Maria-Cristina Al-Matarneh, Lăcrămioara Popovici, Catalina Ionica Ciobanu, Andrei Neamțu, Ionel I. Mangalagiu, Ramona Danac
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Series:	Pharmaceuticals
Subjects:	anticancer cycloaddition molecular docking molecular dynamics pyrroloisoquinoline pyrroloquinoline
Online Access:	https://www.mdpi.com/1424-8247/16/6/865

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