Synthesis and Cytotoxicity Evaluation of Spirocyclic Bromotyrosine Clavatadine C Analogs

Synthesis and Cytotoxicity Evaluation of Spirocyclic Bromotyrosine Clavatadine C Analogs

Marine-originated spirocyclic bromotyrosines are considered as promising scaffolds for new anticancer drugs. In a continuation of our research to develop potent and more selective anticancer compounds, we synthesized a library of 32 spirocyclic clavatadine analogs by replacing the agmatine, i.e., 4-...

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Bibliographic Details
Main Authors: Piyush A. Patel, Tanja Bruun, Polina Ilina, Heidi Mäkkylä, Antti Lempinen, Jari Yli-Kauhaluoma, Päivi Tammela, Paula S. Kiuru
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Marine Drugs
Subjects:
Clavatadine C
spirocyclic bromotyrosines
cytotoxicity
cancer selectivity
marine compounds
melanoma A-375 cell line
Online Access:https://www.mdpi.com/1660-3397/19/7/400

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https://www.mdpi.com/1660-3397/19/7/400

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