Viscoelastic microfluidics: progress and challanges
Modeling microscale manipulation of biofluids Insights into the dynamic behavior of biological fluids on the microscale are enabling more efficient analysis of cells, bacteria, and other small biological particles for research and clinical diagnostics. Blood, saliva and other biofluids have viscoela...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-12-01
|
| Series: | Microsystems & Nanoengineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41378-020-00218-x |
| _version_ | 1818726358501556224 |
|---|---|
| author | Jian Zhou Ian Papautsky |
| author_facet | Jian Zhou Ian Papautsky |
| author_sort | Jian Zhou |
| collection | DOAJ |
| description | Modeling microscale manipulation of biofluids Insights into the dynamic behavior of biological fluids on the microscale are enabling more efficient analysis of cells, bacteria, and other small biological particles for research and clinical diagnostics. Blood, saliva and other biofluids have viscoelastic properties, which means that they exhibit both viscous and elastic behaviors depending on the forces to which they are subjected. These properties shape the migration behaviors of suspended bioparticles in unique ways. Jian Zhou and Ian Papautsky of the University of Illinois at Chicago have reviewed current progress in understanding the migration behaviors in such fluids within microfluidic devices. The authors discuss design principles that have enabled the development of microfluidic systems capable of separating and purifying cells, bacteria, and small vesicles from highly heterogeneous biological specimens, and highlight future challenges that need to be addressed. |
| first_indexed | 2024-12-17T21:56:56Z |
| format | Article |
| id | doaj.art-3d2ced5723f34a15b6d12e39beefa98f |
| institution | Directory Open Access Journal |
| issn | 2055-7434 |
| language | English |
| last_indexed | 2024-12-17T21:56:56Z |
| publishDate | 2020-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Microsystems & Nanoengineering |
| spelling | doaj.art-3d2ced5723f34a15b6d12e39beefa98f2022-12-21T21:31:05ZengNature Publishing GroupMicrosystems & Nanoengineering2055-74342020-12-016112410.1038/s41378-020-00218-xViscoelastic microfluidics: progress and challangesJian Zhou0Ian Papautsky1Department of Bioengineering, University of Illinois at ChicagoDepartment of Bioengineering, University of Illinois at ChicagoModeling microscale manipulation of biofluids Insights into the dynamic behavior of biological fluids on the microscale are enabling more efficient analysis of cells, bacteria, and other small biological particles for research and clinical diagnostics. Blood, saliva and other biofluids have viscoelastic properties, which means that they exhibit both viscous and elastic behaviors depending on the forces to which they are subjected. These properties shape the migration behaviors of suspended bioparticles in unique ways. Jian Zhou and Ian Papautsky of the University of Illinois at Chicago have reviewed current progress in understanding the migration behaviors in such fluids within microfluidic devices. The authors discuss design principles that have enabled the development of microfluidic systems capable of separating and purifying cells, bacteria, and small vesicles from highly heterogeneous biological specimens, and highlight future challenges that need to be addressed.https://doi.org/10.1038/s41378-020-00218-xViscoelastic flowElastic and inertial forceMicrofluidicsNumerical modelingParticle separation and cell sorting3D focusing |
| spellingShingle | Jian Zhou Ian Papautsky Viscoelastic microfluidics: progress and challanges Microsystems & Nanoengineering Viscoelastic flow Elastic and inertial force Microfluidics Numerical modeling Particle separation and cell sorting 3D focusing |
| title | Viscoelastic microfluidics: progress and challanges |
| title_full | Viscoelastic microfluidics: progress and challanges |
| title_fullStr | Viscoelastic microfluidics: progress and challanges |
| title_full_unstemmed | Viscoelastic microfluidics: progress and challanges |
| title_short | Viscoelastic microfluidics: progress and challanges |
| title_sort | viscoelastic microfluidics progress and challanges |
| topic | Viscoelastic flow Elastic and inertial force Microfluidics Numerical modeling Particle separation and cell sorting 3D focusing |
| url | https://doi.org/10.1038/s41378-020-00218-x |
| work_keys_str_mv | AT jianzhou viscoelasticmicrofluidicsprogressandchallanges AT ianpapautsky viscoelasticmicrofluidicsprogressandchallanges |