Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A
Shubhra Chaturvedi,1 Sangeeta Lal,2 Prasenjit Sen,3 Anil K Mishra1 1Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, New Delhi, Delhi, 2Department of Physics, B.S. College, Magadh University, Patna, Bihar, 3School of Physical Sciences, Jawah...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-03-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/synthesis-docking-and-preliminary-in-vitroin-vivo-evaluation-of-mpp-di-peer-reviewed-article-IJN |
| _version_ | 1818999008088031232 |
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| author | Chaturvedi S Lal S Sen P Mishra AK |
| author_facet | Chaturvedi S Lal S Sen P Mishra AK |
| author_sort | Chaturvedi S |
| collection | DOAJ |
| description | Shubhra Chaturvedi,1 Sangeeta Lal,2 Prasenjit Sen,3 Anil K Mishra1 1Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, New Delhi, Delhi, 2Department of Physics, B.S. College, Magadh University, Patna, Bihar, 3School of Physical Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India Abstract: Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT1A receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection limits. Our results demonstrate an easy synthesis of the ligand methoxyphenyl piperazine-dithiocarbamate and silver nanoparticles and their conjugation was free from extraneous impurities. Keywords: receptor imaging, optical imaging, targeted nanoparticles |
| first_indexed | 2024-12-20T22:10:35Z |
| format | Article |
| id | doaj.art-3d2dc69cf6764a598ec8812db10943da |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-20T22:10:35Z |
| publishDate | 2018-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-3d2dc69cf6764a598ec8812db10943da2022-12-21T19:25:10ZengDove Medical PressInternational Journal of Nanomedicine1178-20132018-03-01Volume 13192337267Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1AChaturvedi SLal SSen PMishra AKShubhra Chaturvedi,1 Sangeeta Lal,2 Prasenjit Sen,3 Anil K Mishra1 1Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, New Delhi, Delhi, 2Department of Physics, B.S. College, Magadh University, Patna, Bihar, 3School of Physical Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India Abstract: Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT1A receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection limits. Our results demonstrate an easy synthesis of the ligand methoxyphenyl piperazine-dithiocarbamate and silver nanoparticles and their conjugation was free from extraneous impurities. Keywords: receptor imaging, optical imaging, targeted nanoparticleshttps://www.dovepress.com/synthesis-docking-and-preliminary-in-vitroin-vivo-evaluation-of-mpp-di-peer-reviewed-article-IJNReceptor ImagingOptical ImagingTargeted Nanoparticles. |
| spellingShingle | Chaturvedi S Lal S Sen P Mishra AK Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A International Journal of Nanomedicine Receptor Imaging Optical Imaging Targeted Nanoparticles. |
| title | Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A |
| title_full | Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A |
| title_fullStr | Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A |
| title_full_unstemmed | Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A |
| title_short | Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A |
| title_sort | synthesis docking and preliminary in vitro in vivo evaluation of mpp dithiocarbamate capped silver nanoparticle as dual imaging agent for 5ht1a |
| topic | Receptor Imaging Optical Imaging Targeted Nanoparticles. |
| url | https://www.dovepress.com/synthesis-docking-and-preliminary-in-vitroin-vivo-evaluation-of-mpp-di-peer-reviewed-article-IJN |
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