A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
Futrega et al. challenge the long established chondrogenic differentiation protocol used to induce bone marrow-derived stromal cell (BMSC) differentiation which presumes the need for more than 2 weeks of continuous TGF-β1 exposure. Using a micro-pellet model, they show that BMSC differentiation is t...
Main Authors: | Kathryn Futrega, Pamela G. Robey, Travis J. Klein, Ross W. Crawford, Michael R. Doran |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2021-01-01
|
Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-020-01520-0 |
Similar Items
-
Microtissue Culture Provides Clarity on the Relative Chondrogenic and Hypertrophic Response of Bone-Marrow-Derived Stromal Cells to TGF-β1, BMP-2, and GDF-5
by: Rose Ann G. Franco, et al.
Published: (2023-12-01) -
gene silencing dampens bone marrow stromal cell hypertrophy, but it also dampens chondrogenesis
by: Rose Ann G Franco, et al.
Published: (2023-06-01) -
A Microwell Device for the Efficient Generation of Arrays of Microtissues and Humanized Bone Marrow Micro-Ossicles
by: Kathryn Futrega, et al.
Published: (2023-06-01) -
Human bone marrow-derived stromal cell behavior when injected directly into the bone marrow of NOD-scid-gamma mice pre-conditioned with sub-lethal irradiation
by: Bianca Nowlan, et al.
Published: (2021-04-01) -
Ultra-structural changes and expression of chondrogenic and hypertrophic genes during chondrogenic differentiation of mesenchymal stromal cells in alginate beads
by: Havva Dashtdar, et al.
Published: (2016-03-01)