In vitro Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells

In vitro Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells

The brain is the most complex organ in the body, controlling our highest functions, as well as regulating myriad processes which incorporate the entire physiological system. The effects of prospective therapeutic entities on the brain and central nervous system (CNS) may potentially cause significan...

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Bibliographic Details
Main Authors: Alastair I. Grainger, Marianne C. King, David A. Nagel, H. Rheinallt Parri, Michael D. Coleman, Eric J. Hill
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
iPSC neurons
astrocytes
seizures
in vitro
safety pharmacology
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00590/full

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