Bone Marrow-Derived Conventional, But Not Cloned, Mesenchymal Stem Cells Suppress Lymphocyte Proliferation and Prevent Graft-Versus-Host Disease in Rats
Bone marrow-derived mesenchymal stem cells (MSCs) could exert a potent immunosuppressive effect, and therefore may have a therapeutic potential in T-cell-dependent pathologies. In the present study, we aimed to determine whether MSCs could be used to control graft-versus-host disease (GvHD), a major...
Main Authors: | Yusuke Kitazawa, Xiao-Kang Li M.D., Ph.D., Lin Xie, Ping Zhu, Hiromitsu Kimura, Shiro Takahara |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2012-03-01
|
Series: | Cell Transplantation |
Online Access: | https://doi.org/10.3727/096368911X605510 |
Similar Items
-
Immunoregulatory Properties of Human Bone Marrow Mesenchymal Stem Cells on T Lymphocyte Proliferation
by: Masoumeh Masoumi Karimi, et al.
Published: (2012-02-01) -
Superagonist CD28 Antibody Preferentially Expanded Foxp3-Expressing nTreg Cells and Prevented Graft-Versus-Host Diseases
by: Yusuke Kitazawa, et al.
Published: (2009-05-01) -
Human bone marrow-derived Mesenchymal stem cells suppress T cell proliferation by inducing cell cycle arrest
by: Tong, Chih Kong, et al.
Published: (2008) -
Role of the regulatory T cells CD4+CD25+ and mesenchymal marrow stem cells in suppressing a graft versus host reaction
by: I. A. Korsunsky, et al.
Published: (2022-11-01) -
HLA-G suppresses proliferation of CD4(+) T-lymphocytes.
by: Bainbridge, DR, et al.
Published: (2000)