Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cells
Stem cells have self-renewal, replication, and multidirectional differentiation potential, while progenitor cells are undifferentiated, pluripotent or specialized stem cells. Stem/progenitor cells secrete various factors, such as cytokines, exosomes, non-coding RNAs, and proteins, and have a wide ra...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1286900/full |
| _version_ | 1797449135885910016 |
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| author | Yi-fang He Xia-li Wang Xia-li Wang Shuang-ping Deng Yan-li Wang Qing-qing Huang Shu Lin Shu Lin Guo-rong Lyu Guo-rong Lyu |
| author_facet | Yi-fang He Xia-li Wang Xia-li Wang Shuang-ping Deng Yan-li Wang Qing-qing Huang Shu Lin Shu Lin Guo-rong Lyu Guo-rong Lyu |
| author_sort | Yi-fang He |
| collection | DOAJ |
| description | Stem cells have self-renewal, replication, and multidirectional differentiation potential, while progenitor cells are undifferentiated, pluripotent or specialized stem cells. Stem/progenitor cells secrete various factors, such as cytokines, exosomes, non-coding RNAs, and proteins, and have a wide range of applications in regenerative medicine. However, therapies based on stem cells and their secreted exosomes present limitations, such as insufficient source materials, mature differentiation, and low transplantation success rates, and methods addressing these problems are urgently required. Ultrasound is gaining increasing attention as an emerging technology. Low-intensity pulsed ultrasound (LIPUS) has mechanical, thermal, and cavitation effects and produces vibrational stimuli that can lead to a series of biochemical changes in organs, tissues, and cells, such as the release of extracellular bodies, cytokines, and other signals. These changes can alter the cellular microenvironment and affect biological behaviors, such as cell differentiation and proliferation. Here, we discuss the effects of LIPUS on the biological functions of stem/progenitor cells, exosomes, and non-coding RNAs, alterations involved in related pathways, various emerging applications, and future perspectives. We review the roles and mechanisms of LIPUS in stem/progenitor cells and exosomes with the aim of providing a deeper understanding of LIPUS and promoting research and development in this field. |
| first_indexed | 2024-03-09T14:20:28Z |
| format | Article |
| id | doaj.art-3d34b84b91344d7aa16ae83d6485f22a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-09T14:20:28Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3d34b84b91344d7aa16ae83d6485f22a2023-11-28T13:48:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-11-011410.3389/fendo.2023.12869001286900Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cellsYi-fang He0Xia-li Wang1Xia-li Wang2Shuang-ping Deng3Yan-li Wang4Qing-qing Huang5Shu Lin6Shu Lin7Guo-rong Lyu8Guo-rong Lyu9Department of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartments of Medical Imaging, Quanzhou Medical College, Quanzhou, ChinaDepartment of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaCentre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDiabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, AustraliaDepartment of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartments of Medical Imaging, Quanzhou Medical College, Quanzhou, ChinaStem cells have self-renewal, replication, and multidirectional differentiation potential, while progenitor cells are undifferentiated, pluripotent or specialized stem cells. Stem/progenitor cells secrete various factors, such as cytokines, exosomes, non-coding RNAs, and proteins, and have a wide range of applications in regenerative medicine. However, therapies based on stem cells and their secreted exosomes present limitations, such as insufficient source materials, mature differentiation, and low transplantation success rates, and methods addressing these problems are urgently required. Ultrasound is gaining increasing attention as an emerging technology. Low-intensity pulsed ultrasound (LIPUS) has mechanical, thermal, and cavitation effects and produces vibrational stimuli that can lead to a series of biochemical changes in organs, tissues, and cells, such as the release of extracellular bodies, cytokines, and other signals. These changes can alter the cellular microenvironment and affect biological behaviors, such as cell differentiation and proliferation. Here, we discuss the effects of LIPUS on the biological functions of stem/progenitor cells, exosomes, and non-coding RNAs, alterations involved in related pathways, various emerging applications, and future perspectives. We review the roles and mechanisms of LIPUS in stem/progenitor cells and exosomes with the aim of providing a deeper understanding of LIPUS and promoting research and development in this field.https://www.frontiersin.org/articles/10.3389/fendo.2023.1286900/fullstem cellsexosomeslow-intensity pulsed ultrasounddifferentiationproliferationmigration |
| spellingShingle | Yi-fang He Xia-li Wang Xia-li Wang Shuang-ping Deng Yan-li Wang Qing-qing Huang Shu Lin Shu Lin Guo-rong Lyu Guo-rong Lyu Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cells Frontiers in Endocrinology stem cells exosomes low-intensity pulsed ultrasound differentiation proliferation migration |
| title | Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cells |
| title_full | Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cells |
| title_fullStr | Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cells |
| title_full_unstemmed | Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cells |
| title_short | Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cells |
| title_sort | latest progress in low intensity pulsed ultrasound for studying exosomes derived from stem progenitor cells |
| topic | stem cells exosomes low-intensity pulsed ultrasound differentiation proliferation migration |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1286900/full |
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