Targeting Gas6/TAM in cancer cells and tumor microenvironment
Abstract Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of proteins expressed in many human tissues and regulates several biologic...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-018-0769-1 |
| _version_ | 1818500302103379968 |
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| author | Guiling Wu Zhiqiang Ma Yicheng Cheng Wei Hu Chao Deng Shuai Jiang Tian Li Fulin Chen Yang Yang |
| author_facet | Guiling Wu Zhiqiang Ma Yicheng Cheng Wei Hu Chao Deng Shuai Jiang Tian Li Fulin Chen Yang Yang |
| author_sort | Guiling Wu |
| collection | DOAJ |
| description | Abstract Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of proteins expressed in many human tissues and regulates several biological processes in cells, including proliferation, survival and migration, by binding to its receptors Tyro3, Axl and Mer (TAM). In recent years, the roles of Gas6/TAM signalling in cancer cells and the tumour microenvironment have been studied, and some progress has made in targeted therapy, providing new potential directions for future investigations of cancer treatment. In this review, we introduce the Gas6 and TAM receptors and describe their involvement in different cancers and discuss the roles of Gas6 in cancer cells, the tumour microenvironment and metastasis. Finally, we introduce recent studies on Gas6/TAM targeting in cancer therapy, which will assist in the experimental design of future analyses and increase the potential use of Gas6 as a therapeutic target for cancer. |
| first_indexed | 2024-12-10T20:40:52Z |
| format | Article |
| id | doaj.art-3d356bee0b564e1f9cd6f7d39e7f2550 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-10T20:40:52Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-3d356bee0b564e1f9cd6f7d39e7f25502022-12-22T01:34:23ZengBMCMolecular Cancer1476-45982018-01-0117111010.1186/s12943-018-0769-1Targeting Gas6/TAM in cancer cells and tumor microenvironmentGuiling Wu0Zhiqiang Ma1Yicheng Cheng2Wei Hu3Chao Deng4Shuai Jiang5Tian Li6Fulin Chen7Yang Yang8Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences, Northwest UniversityDepartment of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical UniversityDepartment of Stomatology, Bayi Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Biomedical Engineering, The Fourth Military Medical UniversityDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Aerospace Medicine, The Fourth Military Medical UniversityDepartment of Stomatology, Bayi Hospital Affiliated to Nanjing University of Chinese MedicineKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences, Northwest UniversityKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences, Northwest UniversityAbstract Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of proteins expressed in many human tissues and regulates several biological processes in cells, including proliferation, survival and migration, by binding to its receptors Tyro3, Axl and Mer (TAM). In recent years, the roles of Gas6/TAM signalling in cancer cells and the tumour microenvironment have been studied, and some progress has made in targeted therapy, providing new potential directions for future investigations of cancer treatment. In this review, we introduce the Gas6 and TAM receptors and describe their involvement in different cancers and discuss the roles of Gas6 in cancer cells, the tumour microenvironment and metastasis. Finally, we introduce recent studies on Gas6/TAM targeting in cancer therapy, which will assist in the experimental design of future analyses and increase the potential use of Gas6 as a therapeutic target for cancer.http://link.springer.com/article/10.1186/s12943-018-0769-1Growth arrest-specific 6Cancer cellsTumour microenvironment |
| spellingShingle | Guiling Wu Zhiqiang Ma Yicheng Cheng Wei Hu Chao Deng Shuai Jiang Tian Li Fulin Chen Yang Yang Targeting Gas6/TAM in cancer cells and tumor microenvironment Molecular Cancer Growth arrest-specific 6 Cancer cells Tumour microenvironment |
| title | Targeting Gas6/TAM in cancer cells and tumor microenvironment |
| title_full | Targeting Gas6/TAM in cancer cells and tumor microenvironment |
| title_fullStr | Targeting Gas6/TAM in cancer cells and tumor microenvironment |
| title_full_unstemmed | Targeting Gas6/TAM in cancer cells and tumor microenvironment |
| title_short | Targeting Gas6/TAM in cancer cells and tumor microenvironment |
| title_sort | targeting gas6 tam in cancer cells and tumor microenvironment |
| topic | Growth arrest-specific 6 Cancer cells Tumour microenvironment |
| url | http://link.springer.com/article/10.1186/s12943-018-0769-1 |
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