Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection

Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection

ABSTRACTActivin A strongly influences immune responses; yet, few studies have examined its role in infectious diseases. We measured serum activin A levels in two independent tuberculosis (TB) patient cohorts and in patients with pneumonia and sarcoidosis. Serum activin A levels were increased in TB...

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Bibliographic Details
Main Authors: Natalie E. Nieuwenhuizen, Geraldine Nouailles, Jayne S. Sutherland, Joanna Zyla, Arja H. Pasternack, Jan Heyckendorf, Björn C. Frye, Kerstin Höhne, Ulrike Zedler, Silke Bandermann, Ulrike Abu Abed, Volker Brinkmann, Birgitt Gutbier, Martin Witzenrath, Norbert Suttorp, Gernot Zissel, Christoph Lange, Olli Ritvos, Stefan H. E. Kaufmann
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mBio
Subjects:
activin A
ActRIIB
tuberculosis
latent TB infection
pneumonia
sarcoidosis
Online Access:https://journals.asm.org/doi/10.1128/mbio.03408-23

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