Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil
Background:Pogostemon heyneanus leaves infusions are relevant in ethnopharmacology for treating colds, coughs, headaches, and asthma.Purpose: The essential oil chemical composition of a Pogostemon heyneanus specimen was monthly monitored from October 2021 to July 2022 to evaluate the climatic influe...
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1336878/full |
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| author | Paulo Vinicius Lima Santos Paulo Vinicius Lima Santos Lucas Botelho Jerônimo Weyda Suyane Campos Ribeiro Gustavo Moraes Lopes João Henrique de Castro Leão Neto Hugo Borges Oliveira da Silva Pedro Iuri C. da Silva Pedro Iuri C. da Silva Renata Cunha Silva Joyce Kelly da Silva Jofre Jacob S. Freitas Rosa Helena V. Mourão William N. Setzer José Guilherme S. Maia Pablo Luis B. Figueiredo Pablo Luis B. Figueiredo |
| author_facet | Paulo Vinicius Lima Santos Paulo Vinicius Lima Santos Lucas Botelho Jerônimo Weyda Suyane Campos Ribeiro Gustavo Moraes Lopes João Henrique de Castro Leão Neto Hugo Borges Oliveira da Silva Pedro Iuri C. da Silva Pedro Iuri C. da Silva Renata Cunha Silva Joyce Kelly da Silva Jofre Jacob S. Freitas Rosa Helena V. Mourão William N. Setzer José Guilherme S. Maia Pablo Luis B. Figueiredo Pablo Luis B. Figueiredo |
| author_sort | Paulo Vinicius Lima Santos |
| collection | DOAJ |
| description | Background:Pogostemon heyneanus leaves infusions are relevant in ethnopharmacology for treating colds, coughs, headaches, and asthma.Purpose: The essential oil chemical composition of a Pogostemon heyneanus specimen was monthly monitored from October 2021 to July 2022 to evaluate the climatic influences on its yield and chemical composition and antinociceptive, andanti-inflammatory properties.Methods: The leaves, collected monthly over a 10-month period, were submitted to hydrodistillation. The oils obtained were analyzed by gas chromatography coupled to a mass spectrometer and gas chromatography coupled to flame ionization detector. The P. heyneanus essential oil (PhEO) was tested in vivo to evaluate its peripheral analgesic actions through the abdominal writhing test induced by acetic acid, and peripheral analgesia by tail immersion. Neurogenic and inflammatory pain were evaluated by formalin test, and acute oral toxicity of the oil was also verified.Results: PhEO presented 27 chemical constituents with the highest predominance of patchoulol (43.6%–76.9%), α-bulnesene (0.2%–12.7%), α-guaiene (0.4%–8.9%), seychellene (3.8%–5.1%) and pogostol (0.0%–8.2%). The climatic parameters insolation, humidity, rainfall, and temperature did not influence the essential oil yield or the main chemical constituents, except for pogostol, which presented a strong (r = 0.73) and statistically significant (p < 0.05) correlation with temperature. PhEO did not display toxicity at the maximum 300 mg/kg dosage. The oil showed low peripheral and central analgesic action at 100 mg/kg, while in the neurogenic and inflammatory pain inhibition tests, no actions related to PhEO were observed. In the carrageenan-induced peritonitis test, PhEO did not reduce the migration of leukocytes to the peritoneal cavity compared to the control group.Conclusion:Pogostemon heyneanus is a resistant plant to seasonal influences and a source of patchoulol. Despite ethnopharmacological indications, no in-vivo biological activities such as neurogenic or inflammatory pain were identified in the present work. So, the low influence of the climatic parameters on chemical composition can infer that the low pharmacological activity is also not subject to climatic variations, that is, it does not change due to the climate. |
| first_indexed | 2024-03-08T09:06:15Z |
| format | Article |
| id | doaj.art-3d37e3fc658e4cde82c16fce6bfa720d |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T09:06:15Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3d37e3fc658e4cde82c16fce6bfa720d2024-02-01T04:40:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-02-011510.3389/fphar.2024.13368781336878Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oilPaulo Vinicius Lima Santos0Paulo Vinicius Lima Santos1Lucas Botelho Jerônimo2Weyda Suyane Campos Ribeiro3Gustavo Moraes Lopes4João Henrique de Castro Leão Neto5Hugo Borges Oliveira da Silva6Pedro Iuri C. da Silva7Pedro Iuri C. da Silva8Renata Cunha Silva9Joyce Kelly da Silva10Jofre Jacob S. Freitas11Rosa Helena V. Mourão12William N. Setzer13José Guilherme S. Maia14Pablo Luis B. Figueiredo15Pablo Luis B. Figueiredo16Programa de Pós-graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, BrazilLaboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, BrazilLaboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, BrazilLaboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, BrazilLaboratório de Morfofisiologia Aplicada a Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Belém, BrazilLaboratório de Morfofisiologia Aplicada a Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Belém, BrazilLaboratório de Morfofisiologia Aplicada a Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Belém, BrazilLaboratório de Morfofisiologia Aplicada a Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Belém, BrazilPrograma de Pós-graduação em Farmacologia e Bioquímica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, BrazilLaboratório de Morfofisiologia Aplicada a Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Belém, BrazilPrograma de Pós-graduação em Farmacologia e Bioquímica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, BrazilLaboratório de Morfofisiologia Aplicada a Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Belém, BrazilLaboratório de Bioprospecção e Biologia Experimental, Universidade Federal do Oeste do Pará, Santarém, BrazilAromatic Plant Research Center, Lehi, UT, United StatesPrograma de Pós-graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, BrazilPrograma de Pós-graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, BrazilLaboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, BrazilBackground:Pogostemon heyneanus leaves infusions are relevant in ethnopharmacology for treating colds, coughs, headaches, and asthma.Purpose: The essential oil chemical composition of a Pogostemon heyneanus specimen was monthly monitored from October 2021 to July 2022 to evaluate the climatic influences on its yield and chemical composition and antinociceptive, andanti-inflammatory properties.Methods: The leaves, collected monthly over a 10-month period, were submitted to hydrodistillation. The oils obtained were analyzed by gas chromatography coupled to a mass spectrometer and gas chromatography coupled to flame ionization detector. The P. heyneanus essential oil (PhEO) was tested in vivo to evaluate its peripheral analgesic actions through the abdominal writhing test induced by acetic acid, and peripheral analgesia by tail immersion. Neurogenic and inflammatory pain were evaluated by formalin test, and acute oral toxicity of the oil was also verified.Results: PhEO presented 27 chemical constituents with the highest predominance of patchoulol (43.6%–76.9%), α-bulnesene (0.2%–12.7%), α-guaiene (0.4%–8.9%), seychellene (3.8%–5.1%) and pogostol (0.0%–8.2%). The climatic parameters insolation, humidity, rainfall, and temperature did not influence the essential oil yield or the main chemical constituents, except for pogostol, which presented a strong (r = 0.73) and statistically significant (p < 0.05) correlation with temperature. PhEO did not display toxicity at the maximum 300 mg/kg dosage. The oil showed low peripheral and central analgesic action at 100 mg/kg, while in the neurogenic and inflammatory pain inhibition tests, no actions related to PhEO were observed. In the carrageenan-induced peritonitis test, PhEO did not reduce the migration of leukocytes to the peritoneal cavity compared to the control group.Conclusion:Pogostemon heyneanus is a resistant plant to seasonal influences and a source of patchoulol. Despite ethnopharmacological indications, no in-vivo biological activities such as neurogenic or inflammatory pain were identified in the present work. So, the low influence of the climatic parameters on chemical composition can infer that the low pharmacological activity is also not subject to climatic variations, that is, it does not change due to the climate.https://www.frontiersin.org/articles/10.3389/fphar.2024.1336878/fullorizavolatile constituentspatchouli alcoholanalgesic activitysesquiterpenes |
| spellingShingle | Paulo Vinicius Lima Santos Paulo Vinicius Lima Santos Lucas Botelho Jerônimo Weyda Suyane Campos Ribeiro Gustavo Moraes Lopes João Henrique de Castro Leão Neto Hugo Borges Oliveira da Silva Pedro Iuri C. da Silva Pedro Iuri C. da Silva Renata Cunha Silva Joyce Kelly da Silva Jofre Jacob S. Freitas Rosa Helena V. Mourão William N. Setzer José Guilherme S. Maia Pablo Luis B. Figueiredo Pablo Luis B. Figueiredo Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil Frontiers in Pharmacology oriza volatile constituents patchouli alcohol analgesic activity sesquiterpenes |
| title | Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil |
| title_full | Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil |
| title_fullStr | Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil |
| title_full_unstemmed | Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil |
| title_short | Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil |
| title_sort | exploring the impact of seasonal variations on the chemical composition antinociceptive and anti inflammatory properties of pogostemon heyneanus benth essential oil |
| topic | oriza volatile constituents patchouli alcohol analgesic activity sesquiterpenes |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1336878/full |
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