Scrub Typhus Meningoencephalitis: An Uncommon Cause of Acute Febrile Encephalopathy in the Elderly

Central nervous system infections are an uncommon cause of acute febrile encephalopathy (AFE) in the elderly. Scrub typhus meningoencephalitis is uncommon and often missed in the elderly. A 70-year-old male presented with complaints of intermittent fever, maculopapular rash, and altered sensorium. P...

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Main Authors: Lekshmi V Kesavan Nair, Rajani K Timmalsugur, Vishal Mangal
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Journal of Marine Medical Society
Subjects:
Online Access:http://www.marinemedicalsociety.in/article.asp?issn=0975-3605;year=2022;volume=24;issue=3;spage=101;epage=103;aulast=Kesavan
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author Lekshmi V Kesavan Nair
Rajani K Timmalsugur
Vishal Mangal
author_facet Lekshmi V Kesavan Nair
Rajani K Timmalsugur
Vishal Mangal
author_sort Lekshmi V Kesavan Nair
collection DOAJ
description Central nervous system infections are an uncommon cause of acute febrile encephalopathy (AFE) in the elderly. Scrub typhus meningoencephalitis is uncommon and often missed in the elderly. A 70-year-old male presented with complaints of intermittent fever, maculopapular rash, and altered sensorium. Physical examination revealed fever, tachycardia, tachypnea, maculopapular rash on the trunk, and all four limbs, and an eschar on the right thigh. Initial laboratory evaluation revealed anemia, thrombocytopenia, and azotemia. The cerebrospinal fluid revealed lymphocytic pleocytosis, elevated proteins with normal glucose, and adenosine deaminase. Weil–Felix test was positive. The diagnosis of scrub typhus meningoencephalitis with acute kidney injury and atypical pneumonia was established. A prompt treatment with injection doxycycline and tablet rifampicin led to an uneventful recovery. We report the first case of scrub typhus meningoencephalitis as the cause of AFE in the elderly. This case highlights the importance of clinical examination in any febrile encephalopathy presenting in endemic areas or travelers returning from such places.
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spelling doaj.art-3d3b9a9f666e4d6a8c957dcf56efee492022-12-22T03:31:26ZengWolters Kluwer Medknow PublicationsJournal of Marine Medical Society0975-36052022-01-0124310110310.4103/jmms.jmms_187_20Scrub Typhus Meningoencephalitis: An Uncommon Cause of Acute Febrile Encephalopathy in the ElderlyLekshmi V Kesavan NairRajani K TimmalsugurVishal MangalCentral nervous system infections are an uncommon cause of acute febrile encephalopathy (AFE) in the elderly. Scrub typhus meningoencephalitis is uncommon and often missed in the elderly. A 70-year-old male presented with complaints of intermittent fever, maculopapular rash, and altered sensorium. Physical examination revealed fever, tachycardia, tachypnea, maculopapular rash on the trunk, and all four limbs, and an eschar on the right thigh. Initial laboratory evaluation revealed anemia, thrombocytopenia, and azotemia. The cerebrospinal fluid revealed lymphocytic pleocytosis, elevated proteins with normal glucose, and adenosine deaminase. Weil–Felix test was positive. The diagnosis of scrub typhus meningoencephalitis with acute kidney injury and atypical pneumonia was established. A prompt treatment with injection doxycycline and tablet rifampicin led to an uneventful recovery. We report the first case of scrub typhus meningoencephalitis as the cause of AFE in the elderly. This case highlights the importance of clinical examination in any febrile encephalopathy presenting in endemic areas or travelers returning from such places.http://www.marinemedicalsociety.in/article.asp?issn=0975-3605;year=2022;volume=24;issue=3;spage=101;epage=103;aulast=Kesavanacute febrile encephalopathycase reportelderlymeningoencephalitisscrub typhus
spellingShingle Lekshmi V Kesavan Nair
Rajani K Timmalsugur
Vishal Mangal
Scrub Typhus Meningoencephalitis: An Uncommon Cause of Acute Febrile Encephalopathy in the Elderly
Journal of Marine Medical Society
acute febrile encephalopathy
case report
elderly
meningoencephalitis
scrub typhus
title Scrub Typhus Meningoencephalitis: An Uncommon Cause of Acute Febrile Encephalopathy in the Elderly
title_full Scrub Typhus Meningoencephalitis: An Uncommon Cause of Acute Febrile Encephalopathy in the Elderly
title_fullStr Scrub Typhus Meningoencephalitis: An Uncommon Cause of Acute Febrile Encephalopathy in the Elderly
title_full_unstemmed Scrub Typhus Meningoencephalitis: An Uncommon Cause of Acute Febrile Encephalopathy in the Elderly
title_short Scrub Typhus Meningoencephalitis: An Uncommon Cause of Acute Febrile Encephalopathy in the Elderly
title_sort scrub typhus meningoencephalitis an uncommon cause of acute febrile encephalopathy in the elderly
topic acute febrile encephalopathy
case report
elderly
meningoencephalitis
scrub typhus
url http://www.marinemedicalsociety.in/article.asp?issn=0975-3605;year=2022;volume=24;issue=3;spage=101;epage=103;aulast=Kesavan
work_keys_str_mv AT lekshmivkesavannair scrubtyphusmeningoencephalitisanuncommoncauseofacutefebrileencephalopathyintheelderly
AT rajaniktimmalsugur scrubtyphusmeningoencephalitisanuncommoncauseofacutefebrileencephalopathyintheelderly
AT vishalmangal scrubtyphusmeningoencephalitisanuncommoncauseofacutefebrileencephalopathyintheelderly