Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia
Abstract Progressive spasticity and gait impairment is the functional hallmark of hereditary spastic paraplegia (HSP), but due to inter‐individual variability, longitudinal studies on its progression are scarce. We investigated the progression of gait deficits via mobile digital measurements in conj...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51725 |
| _version_ | 1797851027813171200 |
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| author | Evelyn Loris Malte Ollenschläger Teresa Greinwalder Björn Eskofier Jürgen Winkler Heiko Gaßner Martin Regensburger |
| author_facet | Evelyn Loris Malte Ollenschläger Teresa Greinwalder Björn Eskofier Jürgen Winkler Heiko Gaßner Martin Regensburger |
| author_sort | Evelyn Loris |
| collection | DOAJ |
| description | Abstract Progressive spasticity and gait impairment is the functional hallmark of hereditary spastic paraplegia (HSP), but due to inter‐individual variability, longitudinal studies on its progression are scarce. We investigated the progression of gait deficits via mobile digital measurements in conjunction with clinical and patient‐reported outcome parameters. Our cohort included adult HSP patients (n = 55) with up to 77 months of follow‐up. Gait speed showed a significant association with SPRS progression. Changes in stride time and gait variability correlated to fear of falling and quality of life, providing evidence that gait parameters are meaningful measures of HSP progression. |
| first_indexed | 2024-04-09T19:10:04Z |
| format | Article |
| id | doaj.art-3d3dbf768294458aa7c4a386e41c6410 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-04-09T19:10:04Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-3d3dbf768294458aa7c4a386e41c64102023-04-06T17:45:38ZengWileyAnnals of Clinical and Translational Neurology2328-95032023-03-0110344745210.1002/acn3.51725Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegiaEvelyn Loris0Malte Ollenschläger1Teresa Greinwalder2Björn Eskofier3Jürgen Winkler4Heiko Gaßner5Martin Regensburger6Department of Molecular Neurology Friedrich‐Alexander‐Universität Erlangen‐Nürnberg (FAU) Erlangen GermanyDepartment of Molecular Neurology Friedrich‐Alexander‐Universität Erlangen‐Nürnberg (FAU) Erlangen GermanyDepartment of Molecular Neurology Friedrich‐Alexander‐Universität Erlangen‐Nürnberg (FAU) Erlangen GermanyMachine Learning and Data Analytics Lab, Department Artificial Intelligence in Biomedical Engineering Friedrich‐Alexander‐Universität Erlangen‐Nürnberg (FAU) Erlangen GermanyDepartment of Molecular Neurology Friedrich‐Alexander‐Universität Erlangen‐Nürnberg (FAU) Erlangen GermanyDepartment of Molecular Neurology Friedrich‐Alexander‐Universität Erlangen‐Nürnberg (FAU) Erlangen GermanyDepartment of Molecular Neurology Friedrich‐Alexander‐Universität Erlangen‐Nürnberg (FAU) Erlangen GermanyAbstract Progressive spasticity and gait impairment is the functional hallmark of hereditary spastic paraplegia (HSP), but due to inter‐individual variability, longitudinal studies on its progression are scarce. We investigated the progression of gait deficits via mobile digital measurements in conjunction with clinical and patient‐reported outcome parameters. Our cohort included adult HSP patients (n = 55) with up to 77 months of follow‐up. Gait speed showed a significant association with SPRS progression. Changes in stride time and gait variability correlated to fear of falling and quality of life, providing evidence that gait parameters are meaningful measures of HSP progression.https://doi.org/10.1002/acn3.51725 |
| spellingShingle | Evelyn Loris Malte Ollenschläger Teresa Greinwalder Björn Eskofier Jürgen Winkler Heiko Gaßner Martin Regensburger Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia Annals of Clinical and Translational Neurology |
| title | Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia |
| title_full | Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia |
| title_fullStr | Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia |
| title_full_unstemmed | Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia |
| title_short | Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia |
| title_sort | mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia |
| url | https://doi.org/10.1002/acn3.51725 |
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