| Summary: | <i>Citrus</i>, a genus of flowering plants in the Rutaceae family, holds substantial market importance as a crop worldwide. After prolonged periods of breeding and extensive hybridization, numerous species have emerged, each possessing a unique metabolism that produces a diverse array of secondary metabolites. It is important to note that phenolic compounds, in particular phenols and flavonoids, are among the most important secondary metabolites in <i>Citrus</i> flowers. These chemical compositions of <i>Citrus</i> flowers differ depending on various factors, such as variety, fruit maturity, environmental conditions, storage conditions, and extraction methods. Nevertheless, phenolic compounds extracted from <i>Citrus</i> flowers are well-recognized for their bioavailability characteristics and exhibit numerous health-promoting effects, including antioxidant, anti-inflammatory, anti-cancer, and antibacterial activities in humans. The information contained in this document provides a comprehensive summary of the latest investigations conducted on the subject matter. The aim is to thoroughly comprehend the biological functions of the bioactive compounds in the <i>Citrus</i> flowers and their potential impacts on various biological systems, shedding light on their potential therapeutic applications.
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