Glucose promotes cell growth by suppressing branched-chain amino acid degradation
Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids, which is required for the activation of pro-g...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05362-7 |
| _version_ | 1818343377732632576 |
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| author | Dan Shao Outi Villet Zhen Zhang Sung Won Choi Jie Yan Julia Ritterhoff Haiwei Gu Danijel Djukovic Danos Christodoulou Stephen C. Kolwicz Daniel Raftery Rong Tian |
| author_facet | Dan Shao Outi Villet Zhen Zhang Sung Won Choi Jie Yan Julia Ritterhoff Haiwei Gu Danijel Djukovic Danos Christodoulou Stephen C. Kolwicz Daniel Raftery Rong Tian |
| author_sort | Dan Shao |
| collection | DOAJ |
| description | Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids, which is required for the activation of pro-growth mTOR signaling. |
| first_indexed | 2024-12-13T16:29:37Z |
| format | Article |
| id | doaj.art-3d416561e0a045b687c31a78486d0513 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:29:37Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3d416561e0a045b687c31a78486d05132022-12-21T23:38:31ZengNature PortfolioNature Communications2041-17232018-07-019111710.1038/s41467-018-05362-7Glucose promotes cell growth by suppressing branched-chain amino acid degradationDan Shao0Outi Villet1Zhen Zhang2Sung Won Choi3Jie Yan4Julia Ritterhoff5Haiwei Gu6Danijel Djukovic7Danos Christodoulou8Stephen C. Kolwicz9Daniel Raftery10Rong Tian11Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of WashingtonDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of WashingtonDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of WashingtonDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of WashingtonDepartment of Medicine, NMR Laboratory of Physiological Chemistry, Brigham and Women’s HospitalDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of WashingtonDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of WashingtonDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of WashingtonDepartment of Medicine, NMR Laboratory of Physiological Chemistry, Brigham and Women’s HospitalDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of WashingtonDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of WashingtonDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of WashingtonHypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids, which is required for the activation of pro-growth mTOR signaling.https://doi.org/10.1038/s41467-018-05362-7 |
| spellingShingle | Dan Shao Outi Villet Zhen Zhang Sung Won Choi Jie Yan Julia Ritterhoff Haiwei Gu Danijel Djukovic Danos Christodoulou Stephen C. Kolwicz Daniel Raftery Rong Tian Glucose promotes cell growth by suppressing branched-chain amino acid degradation Nature Communications |
| title | Glucose promotes cell growth by suppressing branched-chain amino acid degradation |
| title_full | Glucose promotes cell growth by suppressing branched-chain amino acid degradation |
| title_fullStr | Glucose promotes cell growth by suppressing branched-chain amino acid degradation |
| title_full_unstemmed | Glucose promotes cell growth by suppressing branched-chain amino acid degradation |
| title_short | Glucose promotes cell growth by suppressing branched-chain amino acid degradation |
| title_sort | glucose promotes cell growth by suppressing branched chain amino acid degradation |
| url | https://doi.org/10.1038/s41467-018-05362-7 |
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