High‐Mobility Group Box‐1 and Liver Disease
High‐mobility group box‐1 (HMGB1) is a ubiquitous protein. While initially thought to be simply an architectural protein due to its DNA‐binding ability, evidence from the last decade suggests that HMGB1 is a key protein participating in the pathogenesis of acute liver injury and chronic liver diseas...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2018-09-01
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| Series: | Hepatology Communications |
| Online Access: | https://doi.org/10.1002/hep4.1223 |
| _version_ | 1797705707595759616 |
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| author | Harriet Gaskell Xiaodong Ge Natalia Nieto |
| author_facet | Harriet Gaskell Xiaodong Ge Natalia Nieto |
| author_sort | Harriet Gaskell |
| collection | DOAJ |
| description | High‐mobility group box‐1 (HMGB1) is a ubiquitous protein. While initially thought to be simply an architectural protein due to its DNA‐binding ability, evidence from the last decade suggests that HMGB1 is a key protein participating in the pathogenesis of acute liver injury and chronic liver disease. When it is passively released or actively secreted after injury, HMGB1 acts as a damage‐associated molecular pattern that communicates injury and inflammation to neighboring cells by the receptor for advanced glycation end products or toll‐like receptor 4, among others. In the setting of acute liver injury, HMGB1 participates in ischemia/reperfusion, sepsis, and drug‐induced liver injury. In the context of chronic liver disease, it has been implicated in alcoholic liver disease, liver fibrosis, nonalcoholic steatohepatitis, and hepatocellular carcinoma. Recently, specific posttranslational modifications have been identified that could condition the effects of the protein in the liver. Here, we provide a detailed review of how HMGB1 signaling participates in acute liver injury and chronic liver disease. |
| first_indexed | 2024-03-12T05:40:22Z |
| format | Article |
| id | doaj.art-3d41f241d771405e87bbf7ddd17890f4 |
| institution | Directory Open Access Journal |
| issn | 2471-254X |
| language | English |
| last_indexed | 2024-03-12T05:40:22Z |
| publishDate | 2018-09-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Hepatology Communications |
| spelling | doaj.art-3d41f241d771405e87bbf7ddd17890f42023-09-03T06:04:03ZengWolters Kluwer Health/LWWHepatology Communications2471-254X2018-09-01291005102010.1002/hep4.1223High‐Mobility Group Box‐1 and Liver DiseaseHarriet Gaskell0Xiaodong Ge1Natalia Nieto2Department of Pathology University of Illinois at Chicago Chicago ILDepartment of Pathology University of Illinois at Chicago Chicago ILDepartment of Pathology University of Illinois at Chicago Chicago ILHigh‐mobility group box‐1 (HMGB1) is a ubiquitous protein. While initially thought to be simply an architectural protein due to its DNA‐binding ability, evidence from the last decade suggests that HMGB1 is a key protein participating in the pathogenesis of acute liver injury and chronic liver disease. When it is passively released or actively secreted after injury, HMGB1 acts as a damage‐associated molecular pattern that communicates injury and inflammation to neighboring cells by the receptor for advanced glycation end products or toll‐like receptor 4, among others. In the setting of acute liver injury, HMGB1 participates in ischemia/reperfusion, sepsis, and drug‐induced liver injury. In the context of chronic liver disease, it has been implicated in alcoholic liver disease, liver fibrosis, nonalcoholic steatohepatitis, and hepatocellular carcinoma. Recently, specific posttranslational modifications have been identified that could condition the effects of the protein in the liver. Here, we provide a detailed review of how HMGB1 signaling participates in acute liver injury and chronic liver disease.https://doi.org/10.1002/hep4.1223 |
| spellingShingle | Harriet Gaskell Xiaodong Ge Natalia Nieto High‐Mobility Group Box‐1 and Liver Disease Hepatology Communications |
| title | High‐Mobility Group Box‐1 and Liver Disease |
| title_full | High‐Mobility Group Box‐1 and Liver Disease |
| title_fullStr | High‐Mobility Group Box‐1 and Liver Disease |
| title_full_unstemmed | High‐Mobility Group Box‐1 and Liver Disease |
| title_short | High‐Mobility Group Box‐1 and Liver Disease |
| title_sort | high mobility group box 1 and liver disease |
| url | https://doi.org/10.1002/hep4.1223 |
| work_keys_str_mv | AT harrietgaskell highmobilitygroupbox1andliverdisease AT xiaodongge highmobilitygroupbox1andliverdisease AT natalianieto highmobilitygroupbox1andliverdisease |