Decoding the coupled decision-making of the epithelial-mesenchymal transition and metabolic reprogramming in cancer

Summary: Cancer metastasis relies on an orchestration of traits driven by different interacting functional modules, including metabolism and epithelial-mesenchymal transition (EMT). During metastasis, cancer cells can acquire a hybrid metabolic phenotype (W/O) by increasing oxidative phosphorylation...

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Bibliographic Details
Main Authors: Madeline Galbraith, Herbert Levine, José N. Onuchic, Dongya Jia
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222019927