The State and Interactions of the System of Cytokines in Autoimmune Thyrotoxicosis
One of the key, as well as regulatory, roles in immune response is given to the system of cytokines. The change in the content of serum opposite’s cytokines in GD is dynamic. The beginning of autoimmune thyrotoxicosis shows the largest amounts of cytokines - IL-1α and IL-1β, IFN-γ, IL-17, TGF-β and...
| Format: | Article |
|---|---|
| Language: | Russian |
| Published: |
Endocrinology Research Centre
2013-12-01
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| Series: | Клиническая и экспериментальная тиреоидология |
| Subjects: | |
| Online Access: | https://cet-endojournals.ru/ket/article/viewFile/6567/4344 |
| _version_ | 1818739457995571200 |
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| collection | DOAJ |
| description | One of the key, as well as regulatory, roles in immune response is given to the system of cytokines. The change in the content of serum opposite’s cytokines in GD is dynamic. The beginning of autoimmune thyrotoxicosis shows the largest amounts of cytokines - IL-1α and IL-1β, IFN-γ, IL-17, TGF-β and IL-10. It has been proved that there is a direct correlation dependence of the degree of the severity of the autoimmune thyrotoxicosis on the content of proinflammatory (IL-1α and IL-1β, IFN-γ, IL-17) and anti-inflammatory TGF-β, IL-10 cytokines in the patient’s blood serum, as well as on the production of anti-receptive thyroid autoantibodies. The benefits of study indexed that, long-term Thiamazole treatment in generally accepted standard doses demonstrates significant reduction of cytokine volume. It has also made it possible to work out the algorithm of the development of autoimmune thyrotoxicosis recurrence. |
| first_indexed | 2024-12-18T01:25:09Z |
| format | Article |
| id | doaj.art-3d46bbce16fd467b83b4419f980800a5 |
| institution | Directory Open Access Journal |
| issn | 1995-5472 2310-3787 |
| language | Russian |
| last_indexed | 2024-12-18T01:25:09Z |
| publishDate | 2013-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Клиническая и экспериментальная тиреоидология |
| spelling | doaj.art-3d46bbce16fd467b83b4419f980800a52022-12-21T21:25:44ZrusEndocrinology Research CentreКлиническая и экспериментальная тиреоидология1995-54722310-37872013-12-0194273010.14341/ket20139427-306425The State and Interactions of the System of Cytokines in Autoimmune ThyrotoxicosisOne of the key, as well as regulatory, roles in immune response is given to the system of cytokines. The change in the content of serum opposite’s cytokines in GD is dynamic. The beginning of autoimmune thyrotoxicosis shows the largest amounts of cytokines - IL-1α and IL-1β, IFN-γ, IL-17, TGF-β and IL-10. It has been proved that there is a direct correlation dependence of the degree of the severity of the autoimmune thyrotoxicosis on the content of proinflammatory (IL-1α and IL-1β, IFN-γ, IL-17) and anti-inflammatory TGF-β, IL-10 cytokines in the patient’s blood serum, as well as on the production of anti-receptive thyroid autoantibodies. The benefits of study indexed that, long-term Thiamazole treatment in generally accepted standard doses demonstrates significant reduction of cytokine volume. It has also made it possible to work out the algorithm of the development of autoimmune thyrotoxicosis recurrence.https://cet-endojournals.ru/ket/article/viewFile/6567/4344autoimmune thyrotoxicosiscytokinesthiamazole |
| spellingShingle | The State and Interactions of the System of Cytokines in Autoimmune Thyrotoxicosis Клиническая и экспериментальная тиреоидология autoimmune thyrotoxicosis cytokines thiamazole |
| title | The State and Interactions of the System of Cytokines in Autoimmune Thyrotoxicosis |
| title_full | The State and Interactions of the System of Cytokines in Autoimmune Thyrotoxicosis |
| title_fullStr | The State and Interactions of the System of Cytokines in Autoimmune Thyrotoxicosis |
| title_full_unstemmed | The State and Interactions of the System of Cytokines in Autoimmune Thyrotoxicosis |
| title_short | The State and Interactions of the System of Cytokines in Autoimmune Thyrotoxicosis |
| title_sort | state and interactions of the system of cytokines in autoimmune thyrotoxicosis |
| topic | autoimmune thyrotoxicosis cytokines thiamazole |
| url | https://cet-endojournals.ru/ket/article/viewFile/6567/4344 |