Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population.
The "thrifty genotype" hypothesis proposes that the high prevalence of type 2 diabetes (T2D) in Native Americans and admixed Latin Americans has a genetic basis and reflects an evolutionary adaptation to a past low calorie/high exercise lifestyle. However, identification of the gene varian...
| Hoofdauteurs: | , , , , , , , , , , , , , |
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| Formaat: | Artikel |
| Taal: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Reeks: | PLoS ONE |
| Online toegang: | http://europepmc.org/articles/PMC3328483?pdf=render |
| _version_ | 1831842407951368192 |
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| author | Desmond D Campbell Maria V Parra Constanza Duque Natalia Gallego Liliana Franco Arti Tandon Tábita Hünemeier Cátira Bortolini Alberto Villegas Gabriel Bedoya Mark I McCarthy Alkes Price David Reich Andrés Ruiz-Linares |
| author_facet | Desmond D Campbell Maria V Parra Constanza Duque Natalia Gallego Liliana Franco Arti Tandon Tábita Hünemeier Cátira Bortolini Alberto Villegas Gabriel Bedoya Mark I McCarthy Alkes Price David Reich Andrés Ruiz-Linares |
| author_sort | Desmond D Campbell |
| collection | DOAJ |
| description | The "thrifty genotype" hypothesis proposes that the high prevalence of type 2 diabetes (T2D) in Native Americans and admixed Latin Americans has a genetic basis and reflects an evolutionary adaptation to a past low calorie/high exercise lifestyle. However, identification of the gene variants underpinning this hypothesis remains elusive. Here we assessed the role of Native American ancestry, socioeconomic status (SES) and 21 candidate gene loci in susceptibility to T2D in a sample of 876 T2D cases and 399 controls from Antioquia (Colombia). Although mean Native American ancestry is significantly higher in T2D cases than in controls (32% v 29%), this difference is confounded by the correlation of ancestry with SES, which is a stronger predictor of disease status. Nominally significant association (P<0.05) was observed for markers in: TCF7L2, RBMS1, CDKAL1, ZNF239, KCNQ1 and TCF1 and a significant bias (P<0.05) towards OR>1 was observed for markers selected from previous T2D genome-wide association studies, consistent with a role for Old World variants in susceptibility to T2D in Latin Americans. No association was found to the only known Native American-specific gene variant previously associated with T2D in a Mexican sample (rs9282541 in ABCA1). An admixture mapping scan with 1,536 ancestry informative markers (AIMs) did not identify genome regions with significant deviation of ancestry in Antioquia. Exclusion analysis indicates that this scan rules out ~95% of the genome as harboring loci with ancestry risk ratios >1.22 (at P < 0.05). |
| first_indexed | 2024-12-23T06:48:10Z |
| format | Article |
| id | doaj.art-3d46c0fb39d34e47a0d1acb47f7f8b09 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T06:48:10Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3d46c0fb39d34e47a0d1acb47f7f8b092022-12-21T17:56:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3357010.1371/journal.pone.0033570Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population.Desmond D CampbellMaria V ParraConstanza DuqueNatalia GallegoLiliana FrancoArti TandonTábita HünemeierCátira BortoliniAlberto VillegasGabriel BedoyaMark I McCarthyAlkes PriceDavid ReichAndrés Ruiz-LinaresThe "thrifty genotype" hypothesis proposes that the high prevalence of type 2 diabetes (T2D) in Native Americans and admixed Latin Americans has a genetic basis and reflects an evolutionary adaptation to a past low calorie/high exercise lifestyle. However, identification of the gene variants underpinning this hypothesis remains elusive. Here we assessed the role of Native American ancestry, socioeconomic status (SES) and 21 candidate gene loci in susceptibility to T2D in a sample of 876 T2D cases and 399 controls from Antioquia (Colombia). Although mean Native American ancestry is significantly higher in T2D cases than in controls (32% v 29%), this difference is confounded by the correlation of ancestry with SES, which is a stronger predictor of disease status. Nominally significant association (P<0.05) was observed for markers in: TCF7L2, RBMS1, CDKAL1, ZNF239, KCNQ1 and TCF1 and a significant bias (P<0.05) towards OR>1 was observed for markers selected from previous T2D genome-wide association studies, consistent with a role for Old World variants in susceptibility to T2D in Latin Americans. No association was found to the only known Native American-specific gene variant previously associated with T2D in a Mexican sample (rs9282541 in ABCA1). An admixture mapping scan with 1,536 ancestry informative markers (AIMs) did not identify genome regions with significant deviation of ancestry in Antioquia. Exclusion analysis indicates that this scan rules out ~95% of the genome as harboring loci with ancestry risk ratios >1.22 (at P < 0.05).http://europepmc.org/articles/PMC3328483?pdf=render |
| spellingShingle | Desmond D Campbell Maria V Parra Constanza Duque Natalia Gallego Liliana Franco Arti Tandon Tábita Hünemeier Cátira Bortolini Alberto Villegas Gabriel Bedoya Mark I McCarthy Alkes Price David Reich Andrés Ruiz-Linares Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population. PLoS ONE |
| title | Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population. |
| title_full | Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population. |
| title_fullStr | Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population. |
| title_full_unstemmed | Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population. |
| title_short | Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population. |
| title_sort | amerind ancestry socioeconomic status and the genetics of type 2 diabetes in a colombian population |
| url | http://europepmc.org/articles/PMC3328483?pdf=render |
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