Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematological malignancy resulting from the genetic alterations and epigenetic dysregulations of the hematopoietic progenitor cells. One-third of children with AML remain at risk of relapse even though outcomes have improved in recent decades. Epigenetic dysregulati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.975819/full |
| _version_ | 1797999053384974336 |
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| author | Huan Xu Yuxi Wen Runming Jin Hongbo Chen |
| author_facet | Huan Xu Yuxi Wen Runming Jin Hongbo Chen |
| author_sort | Huan Xu |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) is a hematological malignancy resulting from the genetic alterations and epigenetic dysregulations of the hematopoietic progenitor cells. One-third of children with AML remain at risk of relapse even though outcomes have improved in recent decades. Epigenetic dysregulations have been identified to play a significant role during myeloid leukemogenesis. In contrast to genetic changes, epigenetic modifications are typically reversible, opening the door to the development of epigenetic targeted therapy. In this review, we provide an overview of the landscape of epigenetic alterations and describe the current progress that has been made in epigenetic targeted therapy, and pay close attention to the potential value of epigenetic abnormalities in the precision and combinational therapy of pediatric AML. |
| first_indexed | 2024-04-11T10:58:32Z |
| format | Article |
| id | doaj.art-3d47a10c285849c4bc3f9e3e783875ef |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-11T10:58:32Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-3d47a10c285849c4bc3f9e3e783875ef2022-12-22T04:28:43ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-09-011010.3389/fped.2022.975819975819Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemiaHuan XuYuxi WenRunming JinHongbo ChenAcute myeloid leukemia (AML) is a hematological malignancy resulting from the genetic alterations and epigenetic dysregulations of the hematopoietic progenitor cells. One-third of children with AML remain at risk of relapse even though outcomes have improved in recent decades. Epigenetic dysregulations have been identified to play a significant role during myeloid leukemogenesis. In contrast to genetic changes, epigenetic modifications are typically reversible, opening the door to the development of epigenetic targeted therapy. In this review, we provide an overview of the landscape of epigenetic alterations and describe the current progress that has been made in epigenetic targeted therapy, and pay close attention to the potential value of epigenetic abnormalities in the precision and combinational therapy of pediatric AML.https://www.frontiersin.org/articles/10.3389/fped.2022.975819/fullacute myeloid leukemiapediatricepigeneticsDNA methylationhistone modificationnon-coding RNAs |
| spellingShingle | Huan Xu Yuxi Wen Runming Jin Hongbo Chen Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia Frontiers in Pediatrics acute myeloid leukemia pediatric epigenetics DNA methylation histone modification non-coding RNAs |
| title | Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia |
| title_full | Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia |
| title_fullStr | Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia |
| title_full_unstemmed | Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia |
| title_short | Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia |
| title_sort | epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia |
| topic | acute myeloid leukemia pediatric epigenetics DNA methylation histone modification non-coding RNAs |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.975819/full |
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