Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia

Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematological malignancy resulting from the genetic alterations and epigenetic dysregulations of the hematopoietic progenitor cells. One-third of children with AML remain at risk of relapse even though outcomes have improved in recent decades. Epigenetic dysregulati...

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Bibliographic Details
Main Authors: Huan Xu, Yuxi Wen, Runming Jin, Hongbo Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pediatrics
Subjects:
acute myeloid leukemia
pediatric
epigenetics
DNA methylation
histone modification
non-coding RNAs
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.975819/full

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