Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions
Diabetes mellitus is classified as the epidemic of the 21st century. Due to the fact that acute carbohydrate metabolism disorders usually do not indicate morphological change, postmortem diagnosis is required to perform biochemical tests. The authors decided to evaluate the usefulness of determining...
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MDPI AG
2020-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/4/236 |
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| author | Karolina Nowak Tomasz Jurek Marcin Zawadzki |
| author_facet | Karolina Nowak Tomasz Jurek Marcin Zawadzki |
| author_sort | Karolina Nowak |
| collection | DOAJ |
| description | Diabetes mellitus is classified as the epidemic of the 21st century. Due to the fact that acute carbohydrate metabolism disorders usually do not indicate morphological change, postmortem diagnosis is required to perform biochemical tests. The authors decided to evaluate the usefulness of determining glucose, lactate, acetone, β-hydroxybutyric acid (BHB), and 1,5-anhydroglucitol (1,5-AG) in postmortem blood/serum, urine, and vitreous humor (VH). Biological material was collected during autopsies. The study group consisted of 50 diabetics, while the control group consisted of 50 non-diabetics, who died a sudden death, with negative test results for the presence of ethyl alcohol and were not resuscitated before death. Statistical analysis was performed using the IBM SPSS Statistics 25 software package. The most statistically significant difference between the two groups was observed for mean 1,5-AG concentration. The authors found many correlations between the concentration of the examined markers in different materials, mainly between blood/serum and VH. The most suitable short-term glycemic marker in postmortem diagnosis is 1,5-AG. Diagnosis may be supported with determinations of acetone and BHB. For medicolegal assessment, the interpretation of the biochemical test results should comprise information on circumstances of death, medical history, results of other toxicological and histopathological tests, and autopsy report. |
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| format | Article |
| id | doaj.art-3d47cc3728f34b57a7276a3ee79d8f60 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T20:22:03Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj.art-3d47cc3728f34b57a7276a3ee79d8f602023-11-19T22:07:14ZengMDPI AGDiagnostics2075-44182020-04-0110423610.3390/diagnostics10040236Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal OpinionsKarolina Nowak0Tomasz Jurek1Marcin Zawadzki2Department of Forensic Medicine, Faculty of Medicine, Wroclaw Medical University, J. Mikulicza-Radeckiego 4 Street, 50-345 Wrocław, PolandDepartment of Forensic Medicine, Faculty of Medicine, Wroclaw Medical University, J. Mikulicza-Radeckiego 4 Street, 50-345 Wrocław, PolandDepartment of Forensic Medicine, Faculty of Medicine, Wroclaw Medical University, J. Mikulicza-Radeckiego 4 Street, 50-345 Wrocław, PolandDiabetes mellitus is classified as the epidemic of the 21st century. Due to the fact that acute carbohydrate metabolism disorders usually do not indicate morphological change, postmortem diagnosis is required to perform biochemical tests. The authors decided to evaluate the usefulness of determining glucose, lactate, acetone, β-hydroxybutyric acid (BHB), and 1,5-anhydroglucitol (1,5-AG) in postmortem blood/serum, urine, and vitreous humor (VH). Biological material was collected during autopsies. The study group consisted of 50 diabetics, while the control group consisted of 50 non-diabetics, who died a sudden death, with negative test results for the presence of ethyl alcohol and were not resuscitated before death. Statistical analysis was performed using the IBM SPSS Statistics 25 software package. The most statistically significant difference between the two groups was observed for mean 1,5-AG concentration. The authors found many correlations between the concentration of the examined markers in different materials, mainly between blood/serum and VH. The most suitable short-term glycemic marker in postmortem diagnosis is 1,5-AG. Diagnosis may be supported with determinations of acetone and BHB. For medicolegal assessment, the interpretation of the biochemical test results should comprise information on circumstances of death, medical history, results of other toxicological and histopathological tests, and autopsy report.https://www.mdpi.com/2075-4418/10/4/236short-term markershyperglycemiapostmortem diagnosisforensic medicine |
| spellingShingle | Karolina Nowak Tomasz Jurek Marcin Zawadzki Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions Diagnostics short-term markers hyperglycemia postmortem diagnosis forensic medicine |
| title | Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions |
| title_full | Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions |
| title_fullStr | Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions |
| title_full_unstemmed | Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions |
| title_short | Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions |
| title_sort | postmortem determination of short term markers of hyperglycemia for the purposes of medicolegal opinions |
| topic | short-term markers hyperglycemia postmortem diagnosis forensic medicine |
| url | https://www.mdpi.com/2075-4418/10/4/236 |
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