Chemical Genetics of Acetyl-CoA Carboxylases
Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of dr...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/2/1704 |
| _version_ | 1818193470450302976 |
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| author | Xuyu Zu Jing Zhong Dixian Luo Jingjing Tan Qinghai Zhang Ying Wu Jianghua Liu Renxian Cao Gebo Wen Deliang Cao |
| author_facet | Xuyu Zu Jing Zhong Dixian Luo Jingjing Tan Qinghai Zhang Ying Wu Jianghua Liu Renxian Cao Gebo Wen Deliang Cao |
| author_sort | Xuyu Zu |
| collection | DOAJ |
| description | Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of drugs for diabetes, obesity and cancers. In mammals, ACCs have both biotin carboxylase (BC) and carboxyltransferase (CT) activity, catalyzing carboxylation of acetyl-CoA to malonyl-CoA. Several classes of small chemicals modulate ACC activity, including cellular metabolites, natural compounds, and chemically synthesized products. This article reviews chemical genetic studies of ACCs and the use of ACCs for targeted therapy of cancers. |
| first_indexed | 2024-12-12T00:46:55Z |
| format | Article |
| id | doaj.art-3d49208b29774685b4da8c42303bd94e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T00:46:55Z |
| publishDate | 2013-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3d49208b29774685b4da8c42303bd94e2022-12-22T00:44:06ZengMDPI AGMolecules1420-30492013-01-011821704171910.3390/molecules18021704Chemical Genetics of Acetyl-CoA CarboxylasesXuyu ZuJing ZhongDixian LuoJingjing TanQinghai ZhangYing WuJianghua LiuRenxian CaoGebo WenDeliang CaoChemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of drugs for diabetes, obesity and cancers. In mammals, ACCs have both biotin carboxylase (BC) and carboxyltransferase (CT) activity, catalyzing carboxylation of acetyl-CoA to malonyl-CoA. Several classes of small chemicals modulate ACC activity, including cellular metabolites, natural compounds, and chemically synthesized products. This article reviews chemical genetic studies of ACCs and the use of ACCs for targeted therapy of cancers.http://www.mdpi.com/1420-3049/18/2/1704acetyl-CoA carboxylasefatty acid biosynthesisACC chemical geneticsACC inhibitorscancer therapy |
| spellingShingle | Xuyu Zu Jing Zhong Dixian Luo Jingjing Tan Qinghai Zhang Ying Wu Jianghua Liu Renxian Cao Gebo Wen Deliang Cao Chemical Genetics of Acetyl-CoA Carboxylases Molecules acetyl-CoA carboxylase fatty acid biosynthesis ACC chemical genetics ACC inhibitors cancer therapy |
| title | Chemical Genetics of Acetyl-CoA Carboxylases |
| title_full | Chemical Genetics of Acetyl-CoA Carboxylases |
| title_fullStr | Chemical Genetics of Acetyl-CoA Carboxylases |
| title_full_unstemmed | Chemical Genetics of Acetyl-CoA Carboxylases |
| title_short | Chemical Genetics of Acetyl-CoA Carboxylases |
| title_sort | chemical genetics of acetyl coa carboxylases |
| topic | acetyl-CoA carboxylase fatty acid biosynthesis ACC chemical genetics ACC inhibitors cancer therapy |
| url | http://www.mdpi.com/1420-3049/18/2/1704 |
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